Pathological Changes in Peripheral Nerve Excitability
Reversing pathological changes in nerve excitability is an important clinical goal. Achieving that goal requires identification of the underlying molecular changes and a clear understanding of how excitability is altered on the basis of those changes. Computational modeling plays an important role in addressing those issues. One approach involves incorporating known or suspected ion channel changes into normal axon models to test whether such changes can explain pathological changes in excitability. An alternative approach involves reproducing the pathological changes in excitability and then working backward to identify which ion channel changes may be involved.
Nerve Injury: From Clinical Symptoms to Molecular Pathology
Peripheral nerves comprise axons of sensory, motor, and autonomic neurons. The signs and symptoms of nerve injury reflect which of those axons are damaged. The most obvious consequence of nerve injury is a loss of normal function which,...
- Ratté S, Zhu Y, Lee KY, Prescott SA (2014) Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain. eLife in pressGoogle Scholar