Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Pathological Changes in Peripheral Nerve Excitability

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_748-1

Definition

Reversing pathological changes in nerve excitability is an important clinical goal. Achieving that goal requires identification of the underlying molecular changes and a clear understanding of how excitability is altered on the basis of those changes. Computational modeling plays an important role in addressing those issues. One approach involves incorporating known or suspected ion channel changes into normal axon models to test whether such changes can explain pathological changes in excitability. An alternative approach involves reproducing the pathological changes in excitability and then working backward to identify which ion channel changes may be involved.

Detailed Description

Nerve Injury: From Clinical Symptoms to Molecular Pathology

Peripheral nerves comprise axons of sensory, motor, and autonomic neurons. The signs and symptoms of nerve injury reflect which of those axons are damaged. The most obvious consequence of nerve injury is a loss of normal function which,...

Keywords

Toxicity Triad 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Neurosciences and Mental HealthThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Department of PhysiologyUniversity of TorontoTorontoCanada