Definition
Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has rapidly become the leading research tool in cognitive neuroscience. Understanding how BOLD signal relates to activity of neural populations is crucial for constraining the interpretation of any fMRI in humans or animals. Here we review how the mean extracellular field potential (mEFP) recorded with extracellular electrodes samples different components of neural activity and how these components relate to the BOLD fMRI signal.
Detailed Description
In this entry, we first review the properties of the neurophysiological signals recorded with extracellular electrodes, and we then review how neurophysiological measures of neural activity related to the BOLD fMRI signal.
Extracellular Medium and Mean Extracellular Field Potential (mEFP)
The extracellular medium surrounding neurons is a volume conductor with a resistivity (specific impedance) that ranges from 200 to 400 Ωcm depending on neural site...
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Logothetis, N.K., Panzeri, S. (2014). Local Field Potential, Relationship to BOLD Signal. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_726-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_726-1
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