Local Field Potential and Movement Disorders
Local field potentials (LFPs) represent the sum of low-frequency electrical activities in the extracellular medium close to a recording electrode. They predominately reflect field changes related to the flow of electrical current at synapses in the vicinity of the electrode, although other tissue components (neuronal spiking, glia potentials) may also contribute. The amplitude of LFPs is affected by the synchrony of dendritic potentials and by the geometry of dendritic arbors. Most of the electrical events that contribute to LFP signal occur within 200–400 μm of the tip of the electrode (Katzner et al. 2009; Xing et al. 2009).
LFPs can be recorded with microelectrodes, usually referenced against an electrode outside of the brain, or with macroelectrodes, usually as differential recordings between two poles of the same electrode. Because most of the spectral power of LFPs is found at relatively low frequencies (<300 Hz), LFP signals are often low-pass filtered (with a filter...
KeywordsDeep Brain Stimulation Essential Tremor Huntington Disease Tourette Syndrome Local Field Potential
This review entry was supported by grants from the National Institute of Health and National Institute of Neurological Disorders and Stroke R01-NS054976 and P50-NS071669 as well as an infrastructure grant from the NIH to the Yerkes Center (P51-RR165, now P51-OD11132).
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