Kinetic Models for PET/SPECT Imaging
PET/SPECT is an in vivo imaging technique used to quantitate the biodistribution of specific molecules labeled with radioisotopes termed radiotracers, radiopharmaceuticals, or radioligands. A kinetic model is a mathematical expression of the kinetics of radiotracers between compartments, usually defined as the virtual chamber of organs/tissues or as states of the radiotracer. The influx or efflux rate of the radiotracer concentration between compartments is expressed as the product of the concentration of the radiotracer and the transfer constant and is known as the rate constant. Applying the numerical time course of the radiotracer concentration, arranged by the kinetic model to measure the dynamic PET/SPECT images, the rate constant between compartments, or the combined rate constants can be mathematically estimated as a physiological function. These physiological parameters can be...
KeywordsCompartment Model Binding Potential Reference Region Arterial Input Function Radioactivity Concentration
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