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Encyclopedia of Computational Neuroscience pp 1–13Cite as

Dynamic Diseases of the Brain

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Synonyms

Dynamical diseases; Periodic diseases

Definition

A dynamic disease of the nervous system is a disease that arises from abnormalities in neural control mechanisms. Whereas traditional approaches for classifying neurological diseases are based on (static) anatomical, cellular, and molecular abnormalities, the focus here is on dynamics, namely, the variation of signs and symptoms of disease as a function of time. The hallmarks of dynamic diseases are sudden, qualitative changes in the temporal pattern of clinical signs. Identifying a neurological disorder as a dynamic disease has two major implications: (1) the observed dynamics and their responses to various manipulations provide important insights into the nature and abnormality of neural control, and (2) based on computational models of the abnormalities, it may be possible to devise novel treatment strategies for dynamic diseases of the brain.

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The concept of a dynamic disease...

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Author information

Authors and Affiliations

  1. Cell & Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK

    Gerold Baier

  2. W.M. Keck Science Center, The Claremont Colleges, Claremont, CA, USA

    John Milton

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  1. Gerold Baier
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  2. John Milton
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Correspondence to Gerold Baier .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Baier, G., Milton, J. (2014). Dynamic Diseases of the Brain. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_503-3

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_503-3

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  • Online ISBN: 978-1-4614-7320-6

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Chapter history

  1. Latest

    Dynamic Diseases of the Brain
    Published:
    11 March 2021

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_503-4

  2. Dynamic Diseases of the Brain
    Published:
    02 June 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_503-3

  3. Original

    Dynamic Diseases of the Brain
    Published:
    22 February 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_503-2

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