Dynamic Diseases of the Brain
A dynamic disease of the nervous system is a disease that arises from abnormalities in neural control mechanisms. Whereas traditional approaches for classifying neurological diseases are based on (static) anatomical, cellular, and molecular abnormalities, the focus here is on dynamics, namely, the variation of signs and symptoms of disease as a function of time. The hallmarks of dynamic diseases are sudden, qualitative changes in the temporal pattern of clinical signs. Identifying a neurological disorder as a dynamic disease has two major implications: (1) the observed dynamics and their responses to various manipulations provide important insights into the nature and abnormality of neural control, and (2) based on computational models of the abnormalities, it may be possible to devise novel treatment strategies for dynamic diseases of the brain.
The concept of a dynamic disease...
KeywordsDeep Brain Stimulation Epileptic Seizure Cochlear Implant Stochastic Resonance Cortical Spreading Depression
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