Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Long Term Depression in the Granule Cell-Purkinje Cell Synapse

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_472-1



Long-term depression (LTD) in the granule cell-Purkinje cell synapse is a reduction of synaptic transmission efficacy, which lasts for hours or longer. The synaptic transmission at this synapse is mediated via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), a member of the ionotropic glutamate receptors, and the direct cause of LTD is a reduction in the numbers of postsynaptic AMPARs. The traditional stimulation to trigger LTD is simultaneous and repeated activation of two excitatory inputs onto Purkinje cells, parallel fibers (PFs) and climbing fibers (CFs), which are neuronal projections originated from granule cells and neurons in inferior olivary nucleus, respectively.

Detailed Description

The LTD at synapses between PFs, axons of granule cells, and Purkinje cells (Fig. 1) was first discovered in the 1980s, and the...


Nitric Oxide Purkinje Cell Serum Response Factor Cell Synapse Paired Stimulation 
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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Center for Functional ConnectomicsKorea Institute of Science and TechnologySeoulRepublic of Korea