Fig. 1
Phenomenon spike-frequency adaptation. (a) Spike train (vertical strokes at the top) of an adapting neuron evoked by the onset of a constant stimulus (green bar at the bottom, I = 15 nS). The spike frequency drops from an initially high onset rate, f 0, in an approximately exponential way down to a lower steady-state rate, f ∞ . (b) Repeating the experiment shown in (a) for various stimulus intensities I (here an injected current) results in the onset f-I curve f 0(I) and the steady-state f-I curve f ∞ (I). Shown are simulations of a single-compartment conductance-based model with an M-type current (the Ermentrout model; Ermentrout 1998; Benda et al. 2010; with \( {\overline{g}}_{\mathrm{Ca}}=0,{\overline{g}}_{\mathrm{AHP}}=0, \) and \( {\overline{g}}_{\mathrm{M}}=8\upmu \mathrm{S}/{\mathrm{cm}}^2 \), the input current is scaled such that 1 nA equals 1 μA/cm2)