Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Slow Oscillations: Physiology

  • Maria Victoria Sanchez-Vives
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_308-1

Synonyms

Definition

Slow oscillations are the coordinated activity of large populations of neurons consisting of an alternation of active periods (Up states) and silent periods (Down states). These oscillations occur with a slow frequency (≤ 1 Hz) in the corticothalamocortical network during slow-wave sleep and deep anesthesia, and they spontaneously occur also in cortical slices. This rhythmic activity emerges in the cortical network when there are no other driving inputs, and it can be considered its default activity. During the active periods, or Up states, neocortical neurons (both excitatory and inhibitory) are depolarized, receive barrages of synaptic inputs, and fire action potentials. During Down states neurons remain hyperpolarized and the synaptic activity is almost nonexistent. This “on-and-off” synaptic activity results in a bimodal distribution of the membrane potential values, an intracellular signature of slow oscillations. During the...

Keywords

Propagation Speed Cortical Network Cortical Slice Slow Oscillation Gamma Power 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Further Reading

  1. ScholarpediaGoogle Scholar
  2. Bazhenov M, Timofeev I (2006) Thalamocortical oscillations. Scholarpedia 1(6):1319CrossRefGoogle Scholar
  3. Okun M, Lampl I (2009) Balance of excitation and inhibition. Scholarpedia 4(8):7467CrossRefGoogle Scholar
  4. Wilson C (2008) Up and down states. Scholarpedia J 3(6):1410PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.ICREA and Systems NeuroscienceIDIBAPSBarcelonaSpain