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Deep Brain Stimulation (Models, Theory, Techniques): Overview

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Encyclopedia of Computational Neuroscience

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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for medically refractory patients with advanced Parkinson’s disease (PD) (Benabid et al. 1991; Blond et al. 1992; Benabid et al. 2002; Deuschl et al. 2006) as well as for patients with early motor complications (Deuschl et al. 2006; Schuepbach et al. 2013). Several neurological diseases, such as Parkinson’s disease (PD) or essential tremor, are characterized by pathological synchronization (Nini et al. 1995; Brown et al. 2001). Parkinsonian resting tremor, for example, seems to origin from a pacemaker-like population of neurons of the basal ganglia firing in a synchronized and oscillatory manner (Hutchison et al. 1997; Hurtado et al. 1999; Magill et al 2001; Trottenberg et al. 2007). In contrast, under healthy conditions these neurons are active in an uncorrelated and desynchronized manner (Nini et al. 1995; Magill et al. 2001).

The standard DBS protocol employs permanent...

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Authors and Affiliations

  1. Department of Neurosurgery, Stanford University, Stanford, CA, USA

    Peter Alexander Tass

  2. Institute of Neuroscience and Medicine and Neuromodulation (INM-7), Research Center Jülich, Jülich, Germany

    Dr. Christian Hauptmann

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  1. Peter Alexander Tass
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  2. Dr. Christian Hauptmann
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Correspondence to Peter Alexander Tass .

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Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Tass, P.A., Hauptmann, C. (2014). Deep Brain Stimulation (Models, Theory, Techniques): Overview. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_284-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_284-1

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  • Online ISBN: 978-1-4614-7320-6

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