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Encyclopedia of Computational Neuroscience pp 1–15Cite as

Hippocampus, Model Excitatory Cells

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Definition

Hippocampus, model excitatory cells refer to mathematical models of neurons that are designed to represent excitatory neurons in hippocampus. Here, we focus on biophysically motivated models of excitatory cells in the hippocampus proper (specifically the CA1 and CA3 pyramidal cells) and the granule cells of the dentate gyrus (DG). This article discusses some common motives for constructing these models and describes a few frequently used models in more detail.

Detailed Description

Introduction

Three principal hippocampal excitatory cell types are CA1 pyramidal cells, CA3 pyramidal cells, and granule cells of the DG (Fig. 1). These cells depolarize their postsynaptic targets through glutamatergic transmission of three main types of ionotropic receptors: α-amino-3-hydroxy-5-methyl-isoxazole-propionic acid (AMPA), kainate, and N-methyl-d-aspartate (NMDA). This is in contrast to hippocampal interneurons, which inhibit their postsynaptic targets through γ-aminobutyric acid...

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Further Reading

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  • Vida I (2010) Morphology of hippocampal neurons. In: Cutsuridis V, Graham B, Cobb S, Vida I (eds) Hippocampal microcircuits. Springer, New York, pp 27–67

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Acknowledgments

We would like to thank Natural Sciences and Engineering Research Council of Canada (NSERC) for their ongoing support as well as an Ontario Graduate Scholarship (OGS) to KAF.

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Authors and Affiliations

  1. Toronto Western Research Institute, University Health Network, Toronto, M5T 2S8, ON, Canada

    Katie A. Ferguson & Dr. Frances K. Skinner

  2. Physiology, University of Toronto, Toronto, M5S 1A1, ON, Canada

    Katie A. Ferguson & Dr. Frances K. Skinner

  3. Medicine (Neurology), University of Toronto, Toronto, M5S 1A1, ON, Canada

    Dr. Frances K. Skinner

Authors
  1. Katie A. Ferguson
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  2. Dr. Frances K. Skinner
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Correspondence to Katie A. Ferguson .

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Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Ferguson, K.A., Skinner, F.K. (2013). Hippocampus, Model Excitatory Cells. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_28-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_28-1

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