Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Connectome, Mouse

  • Yoonsuck ChoeEmail author
  • Jaerock Kwon
  • David Mayerich
  • Louise C. Abbott
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_276-1

Definition

The mouse connectome is a collection of all neuronal connections in the mouse brain, i.e., a complete wiring diagram of the mouse brain.

Detailed Description

The concept of connectome (Sporns et al. 2005; Seung 2012; Sporns 2012) has rapidly grown into a central theme in neuroscience and specifically in computational neuroscience and computational neuroanatomy. So far, as of 2013, the only existing connectome is that of the nematode C. elegans (White et al. 1986). Once obtained, the connectome of the mouse is expected to have significant scientific and clinical impact, due to (1) strong architectural and genetic similarities between the mouse and humans, (2) the extensive body of experimental studies involving the organism, and (3) the availability of a large array of transgenic, knockin, and knockout variants and molecular probes to infer function from the connectome structure (Chinwalla et al. 2002).

Acquisition of the Mouse Connectome

Rapid development in imaging...

This is a preview of subscription content, log in to check access.

References

  1. Allen Institute for Brain Science (2012) ALLEN mouse brain connectivity atlas technical white paper: overview. Technical report October 2012 v.4. Allen Institute for Brain Science. http://connectivity.brain-map.org
  2. Bock DD, Kerlin AM, Andermann ML, Hood G, Wetzel AW, Yurgenson S, Soucy ER, Kim HS, Reid RC (2011) Network anatomy and in vivo physiology of visual cortical neurons. Nature 471:177–182PubMedCentralPubMedCrossRefGoogle Scholar
  3. Chinwalla AT, Cook LL, Delehaunty KD, Fewell GA, Fulton LA, Fulton RS, Mauceli E (2002) Initial sequencing and comparative analysis of the mouse genome. Nature, 420(6915), 520–562PubMedCrossRefGoogle Scholar
  4. Chung JR, Sung C, Mayerich D, Kwon J, Miller DE, Huffman T, Abbott LC, Keyser J, Choe Y (2011) Multiscale exploration of mouse brain microstructures using the knife-edge scanning microscope brain atlas. Front Neuroinform 5:29PubMedCentralPubMedGoogle Scholar
  5. Grange P, Mitra PP (2011) Algorithmic choice of coordinates for injections into the brain: encoding a neuroanatomical atlas on a grid. arXiv:1104.2616v1 [q-Bio.QM]Google Scholar
  6. Hintiryan H, Gou L, Zingg B, Yamashita S, Lyden HM, Song MY, Grewal AK, Zhang X, Toga AW, Dong H-W (2012) Comprehensive connectivity of the mouse main olfactory bulb: analysis and online digital atlas. Front Neuroanat 6:30. doi:10.3389/fnana.2012.00030PubMedCentralPubMedCrossRefGoogle Scholar
  7. Mayerich D, Abbott LC, McCormick BH (2008) Knife-edge scanning microscopy for imaging and reconstruction of three-dimensional anatomical structures of the mouse brain. J Microsc 231:134–143PubMedCrossRefGoogle Scholar
  8. Mikula S, Binding J, Denk W (2012) Staining and embedding the whole mouse brain for electron microscopy. Nat Methods 9:1198–1201PubMedCrossRefGoogle Scholar
  9. Mitra PP (2012) Technical white paper: mouse brain architecture project. Technical report, Cold Spring Harbor Laboratory. http://brainarchitecture.org/mouse/documentation/project-white-paper
  10. Paxinos G, Franklin KBJ (2001) The mouse brain in stereotaxic coordinates, 2nd edn. Academic, San DiegoGoogle Scholar
  11. Ragan T, Kadiri LR, Venkataraju KU, Bahlmann K, Sutin J, Taranda J, Arganda-Carreras I, Kim Y, Seung HS, Osten P (2012) Serial two-photon tomography for automated ex vivo mouse brain imaging. Nat Methods 9:255–258PubMedCentralPubMedCrossRefGoogle Scholar
  12. Seung HS (2012) Connectome: how the brain’s wiring makes us who we are. Houghton Mifflin Harcourt, BostonGoogle Scholar
  13. Sporns O (2012) Discovering the human connectome. MIT Press, Cambridge, MAGoogle Scholar
  14. Sporns O, Tononi G, Kötter R (2005) The human connectome: a structural description of the human brain. PLoS Comput Biol 1:e42PubMedCentralPubMedCrossRefGoogle Scholar
  15. White JG, Southgate E, Thomson JN, Brenner S (1986) The structure of the nervous system of the nematode Caenorhabditis elegans. Philos Trans R Soc Lond B 314:1–340CrossRefGoogle Scholar
  16. Zingg B, Hintiryan H, Gou L, Song MY, Bay M, Bienkowski MS, Dong HW (2014) Neural Networks of the Mouse Neocortex. Cell, 156(5), 1096–1111PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Yoonsuck Choe
    • 1
    Email author
  • Jaerock Kwon
    • 2
  • David Mayerich
    • 3
  • Louise C. Abbott
    • 4
  1. 1.Department of Computer Science and EngineeringTexas A&M UniversityCollege StationUSA
  2. 2.Department of Electrical and Computer EngineeringKettering UniversityFlintUSA
  3. 3.Beckman Institute for Advanced Science and TechnologyUniversity of Illinois at Urbana-ChampaignUrbanaUSA
  4. 4.Department of Veterinary Integrative BiosciencesTexas A&M UniversityCollege StationUSA