Definition
The Drosophila connectome is a comprehensive description of all the connections between subunits comprising the central nervous system (CNS) of the fruit fly, Drosophila melanogaster.
The CNS of Drosophila consists of the brain and ventral ganglion. It has a volume of ~0.07 mm3 (see Rein et al. 2002, Table 1). To compare, this is similar to the volume of a single cortical column in mouse barrel cortex (~0.09 mm3) (Lefort et al. 2009; Hooks et al. 2011). The Drosophila brain can be subdivided into smaller neuropil compartments (Fig. 1), identified through anatomical boundaries (Ito et al. 2014), as well as the overlapping arborizations of the neurons constituting each neuropil compartment (Chiang et al. 2011; Jenett et al. 2012). In total, across these compartments, the Drosophilabrain is thought to contain ~90,000 cells, of which ~90% are neurons. These neurons can be classified into discrete cell types, with stereotypical shapes and synaptic connections, using both human...
This is a preview of subscription content, log in via an institution to check access.
References
Borst A, Haag J, Reiff DF (2010) Fly motion vision. Annu Rev Neurosci 33:49–70
Caron SJ, Ruta V, Abbott L, Axel R (2013) Random convergence of olfactory inputs in the Drosophila mushroom body. Nature 497:113–117
Chiang A-S et al (2011) Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution. Curr Biol 21:1–11
Chou Y-H et al (2010) Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe. Nat Neurosci 13:439–449
Franceschini N, Kirschfeld K, Minke B (1981) Fluorescence of photoreceptor cells observed in vivo. Science 213:1264–1267
Gao S et al (2008) The neural substrate of spectral preference in Drosophila. Neuron 60:328–342
Heisenberg M, Wolf R (1984) Vision in Drosophila. Genetics of microbehaviour. Springer, Berlin
Hooks B et al (2011) Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas. PLoS Biol 9:e1000572
Ito M, Masuda N, Shinomiya K, Endo K, Ito K (2013) Systematic analysis of neural projections reveals clonal composition of the Drosophila brain. Curr Biol 23:644–655
Ito K, Shinomiya K, Ito M et al (2014) A systematic nomenclature for the insect brain. Neuron. in press
Jenett A et al (2012) A GAL4-driver line resource for Drosophila neurobiology. Cell Rep 2:991–1001
Large VRML model with brain structures labeled. Flybrain on-line: http://www.flybrain.org. Accession number: AB00122
Lefort S, Tomm C, Floyd Sarria J-C, Petersen CC (2009) The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. Neuron 61:301–316
Meinertzhagen IA, Lee C-H (2011) The genetic analysis of functional connectomics in Drosophila. Adv Genet 80:99–151
Meinertzhagen I, O’neil S (1991) Synaptic organization of columnar elements in the lamina of the wild type in Drosophila melanogaster. J Comp Neurol 305:232–263
Murthy M, Fiete I, Laurent G (2008) Testing odor response stereotypy in the Drosophila mushroom body. Neuron 59:1009–1023
Rein K, Zöckler M, Mader MT, Grübel C, Heisenberg M (2002) The Drosophila standard brain. Curr Biol 12:227–231
Rivera-Alba M et al (2011) Wiring economy and volume exclusion determine neuronal placement in the Drosophila brain. Curr Biol 21:2000–2005
Takemura S-Y et al (2013) A visual motion detection circuit suggested by Drosophila connectomics. Nature 500:175–181
Tuthill JC, Nern A, Holtz SL, Rubin GM, Reiser MB (2013) Contributions of the 12 neuron classes in the fly lamina to motion vision. Neuron 79:128–140
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2019 Springer Science+Business Media, LLC, part of Springer Nature
About this entry
Cite this entry
Bharioke, A., Scheffer, L.K., Chklovskii, D.B., Meinertzhagen, I.A. (2019). Connectome, Drosophila. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_275-2
Download citation
DOI: https://doi.org/10.1007/978-1-4614-7320-6_275-2
Received:
Accepted:
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-7320-6
Online ISBN: 978-1-4614-7320-6
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences
Publish with us
Chapter history
-
Latest
Connectome,- Published:
- 07 September 2019
DOI: https://doi.org/10.1007/978-1-4614-7320-6_275-2
-
Original
Connectome- Published:
- 07 March 2014
DOI: https://doi.org/10.1007/978-1-4614-7320-6_275-1