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Control of Breathing, Integration of Adaptive Reflexes

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Encyclopedia of Computational Neuroscience

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Models of respiratory regulation – as with many physiological control systems – have traditionally invoked the Sherringtonian reflex paradigm (Sherrington 1906) in which the response to any afferent input is assumed to follow a static stimulus–response relationship that adds to other stimulus–response relationships to produce the overall response. Such a reductionist analysis has set the foundation for our understanding of various respiratory control mechanisms, such as central and peripheral chemoreflex, lung inflation and deflation reflexes, and exercise reflex via various chemical and mechanical afferent feedbacks and feedforward commands. Under this Sherringtonian framework, such feedback and feedforward controls are taken as a combination of simple reflex drives acting in parallel that are integrated algebraically by the brainstem respiratory controller in determining the resultant respiratory rhythm (inspiratory/expiratory duration) and motor pattern (tidal volume) in...

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Authors and Affiliations

  1. Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Room P6416, Academic 1, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong

    Chung Tin

  2. Institute for Medical Engineering and Science, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Bldg E25-250, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

    Chi-Sang Poon

Authors
  1. Chung Tin
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  2. Chi-Sang Poon
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Correspondence to Chung Tin .

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Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Tin, C., Poon, CS. (2014). Control of Breathing, Integration of Adaptive Reflexes. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_249-1

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_249-1

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