Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Control of Breathing, Integration of Adaptive Reflexes

  • Chung TinEmail author
  • Chi-Sang Poon
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_249-1


Models of respiratory regulation – as with many physiological control systems – have traditionally invoked the Sherringtonian reflex paradigm (Sherrington 1906) in which the response to any afferent input is assumed to follow a static stimulus–response relationship that adds to other stimulus–response relationships to produce the overall response. Such a reductionist analysis has set the foundation for our understanding of various respiratory control mechanisms, such as central and peripheral chemoreflex, lung inflation and deflation reflexes, and exercise reflex via various chemical and mechanical afferent feedbacks and feedforward commands. Under this Sherringtonian framework, such feedback and feedforward controls are taken as a combination of simple reflex drives acting in parallel that are integrated algebraically by the brainstem respiratory controller in determining the resultant respiratory rhythm (inspiratory/expiratory duration) and motor pattern (tidal volume) in...


Internal Model Respiratory Control Primary Stimulus Peripheral Chemoreceptor Neural Integrator 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Mechanical and Biomedical EngineeringCity University of Hong KongKowloon TongHong Kong
  2. 2.Institute for Medical Engineering and Science, Harvard-MIT Division of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA