Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Peripheral Nerve Interface Applications: Neuropathic Pain

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_203-1



Neuropathic pain (NP) is a direct consequence of lesions or disease affecting the central or peripheral somatosensory system. Peripheral nerve interfaces are systems for delivery of therapeutic modalities directly to the peripheral nervous system, such as the management of NP.

Detailed Description

Pain is a subjective feeling of physical suffering and discomfort from the sensory modality of nociception (pain perception) by activation of terminal receptors. A direct activation of pain pathways can also result in the perception of pain without extrinsic activation of end receptors. Such “neuropathic pain” may be caused by disease or injury. The International Association for the Study of Pain (IASP) defined NP as “pain caused by a lesion or disease of the somatosensory system” (IASP 2011; Jensen et al. 2011).

Patients with NP may have reduced sensation to touch and temperature in affected areas (negative signs and symptoms). They may...


Neuropathic Pain Spinal Dorsal Horn Peripheral Nerve Stimulation Phantom Limb Pain Occipital Neuralgia 
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Further Reading

  1. Devor M (2012) Peripheral neuropathic pain. In: Schmidt RF, Gebhart GF (eds) Encyclopedia of pain. Springer. http://link.springer.com/book/10.1007%2F978-3-642-28753-4
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  3. Slavin KV (2011) Peripheral nerve stimulation, vol 24, Progress in neurological surgery. Karger, BaselGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Neural Engineering Center, Department of Biomedical EngineeringCase Western Reserve UniversityClevelandUSA