Signaling Pathways, Modeling of
The use of models to study the dynamical behavior of a biological (sub)system described as a set of biochemical reactions and diffusion. Here, the evolution in time for quantities such as protein concentrations or amount of enzyme activation is typically described using ordinary differential equations. The evolution in time of second messengers is typically described using partial differential equations. Alternatively, stochastic methods can be used to determine evolution in time of all molecules in a simulation.
The development of quantitative models at multiple spatial and temporal scales is necessary for integrating the knowledge obtained from diverse experimental approaches into a coherent picture. Such models represent current knowledge in a compact and standardized way and constitute a tool for guiding experiments and generating predictions.
Modeling of intracellular signaling within the field of computational neuroscience...
KeywordsEnzymatic Reaction Dendritic Spine Biochemical Reaction Deterministic Approach Reaction Cascade
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