Skip to main content

Protein Kinase C, Models of

  • Living reference work entry
  • First Online:
Book cover Encyclopedia of Computational Neuroscience
  • 195 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Antunes G, De Schutter E (2012) A stochastic signaling network mediates the probabilistic induction of cerebellar long-term depression. J Neurosci 32(27):9288–300

    Google Scholar 

  • Ajay SM, Bhalla US (2007) A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity. HFSP J 1:49–66

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bhalla US, Iyengar R (1999) Emergent properties of networks of biological signaling pathways. Science 283:381–387

    Article  CAS  PubMed  Google Scholar 

  • Chang CW, Poteet E, Schetz JA, Gümüs ZH, Weinstein H (2009) Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology 56(Suppl 1):213–225

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dupont G, Lokenye EF, Challiss RA (2011) A model for Ca2+ oscillations stimulated by the type 5 metabotropic glutamate receptor: an unusual mechanism based on repetitive, reversible phosphorylation of the receptor. Biochimie 93:2132–2138

    Article  CAS  PubMed  Google Scholar 

  • Kikuchi S, Fujimoto K, Kitagawa N, Fuchikawa T, Abe M, Oka K, Takei K, Tomita M (2003) Kinetic simulation of signal transduction system in hippocampal long-term potentiation with dynamic modeling of protein phosphatase 2A. Neural Netw 16:1389–1398

    Article  PubMed  Google Scholar 

  • Kim B, Hawes SL, Gillani F, Wallace LJ, Blackwell KT (2013) Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity. PLoS Comput Biol 9:e1002953

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kotaleski JH, Lester D, Blackwell KT (2002) Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval. Integr Physiol Behav Sci 37:265–292

    Article  PubMed  Google Scholar 

  • Kuroda S, Schweighofer N, Kawato M (2001) Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation. J Neurosci 21:5693–5702

    CAS  PubMed  Google Scholar 

  • Newton AC (2001) Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101:2353–2364

    Article  CAS  PubMed  Google Scholar 

  • Oancea E, Meyer T (1998) Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell 95:307–318

    Article  CAS  PubMed  Google Scholar 

  • Ogasawara H, Kawato M (2009) Computational models of cerebellar long-term memory. In: Nakanishi S et al (eds) Systems biology. Springer, Tokyo/New York, pp 169–182

    Chapter  Google Scholar 

  • Sajikumar S, Navakkode S, Sacktor TC, Frey JU (2005) Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depression. J Neurosci 25:5750–5756

    Article  CAS  PubMed  Google Scholar 

  • Smolen P, Baxter DA, Byrne JH (2012) Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model. PLoS Comput Biol 8:e1002620

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Tanaka K, Khiroug L, Santamaria F, Doi T, Ogasawara H, Ellis-Davies GC, Kawato M, Augustine GJ (2007) Ca2+ requirements for cerebellar long-term synaptic depression: role for a postsynaptic leaky integrator. Neuron 54:787–800

    Article  CAS  PubMed  Google Scholar 

  • Torrecillas A, Laynez J, Menéndez M, Corbalán-García S, Gómez-Fernández JC (2004) Calorimetric study of the interaction of the C2 domains of classical protein kinase C isoenzymes with Ca2+ and phospholipids. Biochemistry 43:11727–11739

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kim L. Blackwell .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this entry

Cite this entry

Blackwell, K.L. (2014). Protein Kinase C, Models of. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_193-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_193-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics