Slow Oscillations and Epilepsy: Network Models
Network models are very useful tools to investigate the genesis of oscillatory behavior such as epileptic seizures. During many types of seizures, the brain produces oscillatory spike-and-wave discharges, which are particularly prominent for absence seizures. It was found that the thalamocortical mechanisms leading to spindle oscillations and their large-scale synchrony can explain spike-and-wave oscillations, if the excitability of the cerebral cortex is augmented. These pathological oscillations can be reproduced by network models involving the reciprocal interaction between thalamus and cortex.
Many types of epileptic seizures display very synchronized oscillations producing a typical electroencephalogram (EEG) pattern consisting of one or several sharp deflections (“spikes”) followed by a surface-positive “wave.” Spike-and-wave patterns of similar characteristics are also seen in a number of experimental models in cats, rats, mice, and...
- Destexhe A (2013) Network models of absence seizures. In: Faingold CL, Blumenfeld H (eds) Neuronal networks in brain function, CNS disorders and therapeutics. Elsevier, Amsterdam (in press)Google Scholar
- Destexhe A, McCormick DA, Sejnowski TJ (1993) A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophys J 65:2474–2478Google Scholar
- Vergnes M, Marescaux C (1992) Cortical and thalamic lesions in rats with genetic absence epilepsy. J Neural Transm 35(Suppl):71–83Google Scholar
- Destexhe A (2007) Spike-and-wave oscillations. Scholarpedia 2:1402. http://www.scholarpedia.org/article/Spike-and-Wave_Oscillations
- Destexhe A, Sejnowski TJ (2001) Thalamocortical assemblies. Oxford University Press, OxfordGoogle Scholar