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Encyclopedia of Computational Neuroscience pp 1–17Cite as

Calcium-Dependent Exocytosis, Biophysical Models of

Synonyms

Non-constitutive exocytosis; Regulated exocytosis

Definition

Calcium-dependent exocytosis is the biochemically controlled fusion of the bilipid secretory vesicle membrane with the bilipid cell membrane, triggered by the binding of several Ca2+ ions to control proteins such as synaptotagmins anchored at the interface between these two membranes. Exocytosis results in the release of vesicle contents into the extracellular space, namely, the release of neurotransmitter into the synaptic cleft in the case of neuronal synapses and neuromuscular junctions or the secretion of hormone into the bloodstream in the case of endocrine cells. Exocytosis also allows the transmembrane proteins contained in the vesicle membrane to be incorporated into the cell membrane, although such membrane protein trafficking is more characteristic of Ca2+-independent, constitutive exocytosis.

Detailed Description

In synapses, neuromuscular junctions, and endocrine cells, fast Ca2+-triggered exocytosis of...

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  1. Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ, USA

    Victor Matveev

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  1. Victor Matveev
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Correspondence to Victor Matveev .

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  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Matveev, V. (2014). Calcium-Dependent Exocytosis, Biophysical Models of. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_178-1

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  1. Latest

    Biophysical Models of Calcium-Dependent Exocytosis
    Published:
    17 January 2020

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_178-2

  2. Original

    Calcium-Dependent Exocytosis, Biophysical Models of
    Published:
    05 April 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_178-1

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