Definition
Dynamic clamp is an electrophysiological technique for introducing simulated electrical components into biological cells using a real-time closed loop between the cell and a computer or another electronic device. Classic dynamic clamp protocols build a voltage-dependent current injection cycle to implement artificial membrane or synaptic conductances in the cell membrane of biological neurons. These protocols are employed to assess a large variety of neuronal computational properties and are widely applied for studying the physiology of neural systems at the cellular and circuit levels.
Detailed Description
History
The use of closed-loop feedback interactions with living neurons for observation and control purposes goes back to the beginnings of electrophysiology when the voltage clamp technique was developed (Marmont 1949; Cole 1955). The voltage clamp technique measures currents across the membrane of excitable cells while holding the membrane potential at a constant...
References
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Nowotny, T., Varona, P. (2014). Dynamic Clamp Technique. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_126-2
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_126-2
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