Skip to main content

Databases and Data Repositories in Computational Neuroscience: Overview

  • Reference work entry
  • First Online:
  • 291 Accesses

Definition

Computational neuroscience research often produces models that help explain empirical data and provide predictions about the biological systems that produce the data. Empirical and theoretical researchers can benefit from resources that facilitate model publication and exchange and provide neuroscience data that informs and contains these existing and future models.

Detailed Description

Databases of Computational Models

One category of databases in computational neuroscience is those that focus on computational models. The BioModels database (Li et al. 2010; Vijayalakshmi et al. 2013) is a general repository of computational models of biological processes that includes some models from neuroscience. The SenseLab database, ModelDB, (Migliore et al. 2003) provides a resource for published neuroscience models in a variety of formats. Many of these were developed specifically for simulating the electrophysiological and neurochemical properties of single neurons and networks of...

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   2,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Ascoli GA, Donohue DE, Halavi M (2007) Neuromorpho.org: a central resource for neuronal morphologies. J Neurosci 27(35):9247–9251

    CAS  PubMed  Google Scholar 

  • Bakker R, Wachtler T, Diesmann M (2012) Cocomac 2.0 and the future of tract-tracing databases. Front Neuroinform 6:30

    PubMed Central  PubMed  Google Scholar 

  • Bota M, Dong H-W, Swanson L (2005) Brain architecture management system. Neuroinformatics 3(1):15–48

    PubMed  Google Scholar 

  • Bug WJ, Ascoli GA, Grethe JS, Gupta A, Fennema-Notestine C, Laird AR, Larson SD, Rubin D, Shepherd GM, Turner JA, Martone ME (2008) The NIFSTD and BIRNLex vocabularies: building comprehensive ontologies for neuroscience. Neuroinformatics 6(3):175–194

    PubMed Central  PubMed  Google Scholar 

  • Crasto CJ, Marenco LN, Liu N, Morse TM, Cheung K-H, Lai PC, Bahl G, Masiar P, Lam HYK, Lim E, Chen H, Nadkarni P, Migliore M, Miller PL, Shepherd GM (2007) SenseLab: new developments in disseminating neuroscience information. Brief Bioinform 8(3):150–162

    PubMed Central  CAS  PubMed  Google Scholar 

  • Gardner D et al (2008) The neuroscience information framework: a data and knowledge environment for neuroscience. Neuroinformatics 6(3):149–165

    PubMed Central  PubMed  Google Scholar 

  • Glaser JR, Glaser EM (1990) Neuron imaging with neurolucida – a PC-based system for image combining microscopy. Comput Med Imaging Graph 14(5):307–317

    CAS  PubMed  Google Scholar 

  • Gleeson P, Crook S, Cannon RC, Hines ML, Billings GO, Farinella M, Morse TM, Davison AP, Ray S, Bhalla US, Barnes SR, Dimitrova YD, Silver RA (2010a) NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS Comput Biol 6(6):e1000815

    PubMed Central  PubMed  Google Scholar 

  • Gleeson P, Piasini E, Crook S, Cannon R, Steuber V, Jaeger D, Solinas S, DAngelo E, Silver RA (2010b) The open source brain initiative: enabling collaborative modelling in computational neuroscience. BMC Neurosci 13(1):1–2

    Google Scholar 

  • Hamilton DJ, Shepherd GM, Martone ME, Ascoli GA (2012) An ontological approach to describing neurons and their relationships. Front Neuroinform 6:15

    PubMed Central  PubMed  Google Scholar 

  • Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117(4):500–544

    PubMed Central  CAS  PubMed  Google Scholar 

  • Imam FT, Larson SD, Bandrowski A, Grethe JS, Gupta A, Martone ME (2012) Development and use of ontologies inside the neuroscience information framework: a practical approach. Front Genet 3:111

    PubMed Central  PubMed  Google Scholar 

  • Laird AR, Lancaster JL, Fox PT (2004) Brainmap: the social evolution of a functional neuroimaging database. Neuroinformatics 3:65–78

    Google Scholar 

  • Larson SD, Martone ME (2009) Ontologies for neuroscience: what are they and what are they good for? Front Neurosci 3:1

    Google Scholar 

  • Larson SD, Martone ME (2013) NeuroLex.org: an online framework for neuroscience knowledge. Front Neuroinform 7:18

    PubMed Central  PubMed  Google Scholar 

  • Lein ES et al (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445(7124):168–176

    CAS  PubMed  Google Scholar 

  • Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novere N, Laibe C (2010) BioModels database: an enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol 4:92

    PubMed Central  PubMed  Google Scholar 

  • Marcus DS, Harms MP, Snyder AZ, Jenkinson M, Wilson JA, Glasser MF, Barch DM, Archie KA, Burgess GC, Ramaratnam M, Hodge M, Horton W, Herrick R, Olsen T, McKay M, House M, Hileman M, Reid E, Harwell J, Coalson T, Schindler T, Elam JS, Curtiss SW, WU-Minn HCP Consortium, Van Essen DC (2013) Human connectome project informatics: quality control, database services, and data visualization. Neuroimage 80:202–219

    PubMed  Google Scholar 

  • Markram H (2006) The blue brain project. Nat Rev Neurosci 7(2):153–160

    CAS  PubMed  Google Scholar 

  • Martone ME, Zhang S, Gupta A, Qian X, He H, Price DL, Wong M, Santini S, Ellisman MH (2003) The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy. Neuroinformatics 1(4):375–379

    Google Scholar 

  • Martone ME, Tran J, Wong WW, Sargis J, Fong L, Larson SD, Lamont SP, Gupta A, Ellisman MH (2009) Cell centered database project: an update on building community resources for managing and sharing 3D imaging data. J Struct Biol 161(3):220–231

    Google Scholar 

  • Migliore M, Morse TM, Davison AP, Marenco L, Shepherd GM, Hines M (2003) ModelDB. Neuroinformatics 1(1):135–139

    PubMed Central  PubMed  Google Scholar 

  • Ranjan R, Khazen G, Gambazzi L, Ramaswamy S, Hill SL, Schrmann F, Markram H (2011) Channelpedia: an integrative and interactive database for ion channels. Front Neuroinform 5:36

    PubMed Central  PubMed  Google Scholar 

  • Stephan KE, Kamper L, Bozkurt A, Burns GA, Young MP, Ktter R (2001) Advanced database methodology for the collation of connectivity data on the macaque brain (CoCoMac). Philos Trans R Soc Lond B Biol Sci 356(1412):1159–1186

    PubMed Central  CAS  PubMed  Google Scholar 

  • Tripathy SJ, Savitskaya J, Burton SD, Urban NN, Gerkin RC (2014) NeuroElectro: a window to the world’s Neuron electrophysiology data. Frontiers in Neuroinformatics 8:40

    Google Scholar 

  • Vijayalakshmi C, Laibe C, Le Novere N (2013) Biomodels database: a repository of mathematical models of biological processes. Methods Mol Biol 1021:189–199

    Google Scholar 

  • Yu T, Lloyd CM, Nickerson DP, Cooling MT, Miller AK, Garny A, Terk-ildsen JR, Lawson J, Britten RD, Hunter PJ, Nielsen PM (2011) The physiome model repository 2. Bioinformatics 27(5):743–744

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard C. Gerkin .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this entry

Cite this entry

Gerkin, R.C., Tripathy, S.J., Crook, S., Kotaleski, J.H. (2015). Databases and Data Repositories in Computational Neuroscience: Overview. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6675-8_780

Download citation

Publish with us

Policies and ethics