Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Rhythm Generation in Embryonic Chick Spinal Cord

  • Joel Tabak
  • Peter Wenner
  • Michael J. O’Donovan
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_45

Definition

Early in development, vertebrate neural networks become spontaneously active in the absence of sensory inputs. Their activity is episodic and differs from the activity that will take place in the fully mature, functional network. In the isolated chick spinal cord preparation, episodic activity starts at embryonic day (E) 4 and lasts about 10 days. At E4, it is characterized by one short bout of synchronous activity along the ventral spinal cord occurring every 2 min. By E10, episodes can last over a minute and are comprised of several cycles of activity. Many different developing networks also produce episodic activity; this activity plays an important role in the maturity of the synaptic networks in which it is expressed (Blankenship and Feller 2010; O’Donovan 1999).

Detailed Description

Spontaneous network activity was first observed behaviorally as embryonic motility (Preyer 1937). This spinally generated activity occurs in bouts separated by periods of quiescence....
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Copyright information

© Springer Science+Business Media New York (outside the USA) 2015

Authors and Affiliations

  • Joel Tabak
    • 1
  • Peter Wenner
    • 2
  • Michael J. O’Donovan
    • 3
  1. 1.Florida State UniversityTallahasseeUSA
  2. 2.Emory UniversityAtlantaUSA
  3. 3.National Institute of Neurological Disorders and StrokeBethesdaUSA