Reduced Morphology Models
Reference work entry
Reduced morphology models are simplified computational models obtained by collapsing the dendritic tree of a detailed neuron model, in such a way to preserve as much as possible the original membrane dynamics.
Morphologically detailed neuron models are based on 3D anatomical cell reconstructions and describe how the spatial dendritic structure of a neuron together with the kinetic properties and distributions of ion channels and synaptic inputs contributes to the dynamics and functionality of a neuron. These compartmental neuron models are usually composed of hundreds of dendritic branches (Fig. 1) with nonlinear membrane properties.
- Clements JD (1986) Synaptic Transmission and Integration in Spinal Motoneurones. Ph.D. thesis, Australian National University, CanberraGoogle Scholar
- Destexhe A (2001) Simplified models of neocortical pyramidal cells preserving somatodendritic voltage attenuation. Neurocomputing 38:167–173Google Scholar
- Evans JD (2000) Analysis of a multiple equivalent cylinder model with generalized taper. IMA J Math Med Biol 17:347Google Scholar
- Marasco A, Limongiello A, Migliore M (2013) Using Strahler’s analysis to reduce up to 200-fold the run time of realistic neuron models. Sci Rep 2:2934Google Scholar
- Rall W (1964) Theoretical significance of dendritic trees for neuronal input-output relations. In: Reiss RF (ed) Neural theory and modeling. Stanford University Press, Stanford, pp 73–97Google Scholar
- Rall W, Segev I, Rinzel J, Shepherd GM (eds) (1995) The theoretical foundation of dendritic function. MITPress, CambridgeGoogle Scholar
- Schierwagen AK (1994) Exploring the computational capabilities of single neurons by continuous cable modelling. In: van Pelt J, Corner MA, Uylings HBM, Lopes da Silva FH (eds) The self-organizing brain from growth cones to functional networks, vol 102, Progress in brain research. Elsevier, Amsterdam, pp 151–167Google Scholar
- Stratford K, Mason A, Larkman A, Major G, Jack JJB (1989) The modeling of pyramidal neurones in the visual cortex. In: Durbin R, Miall C, Mitchison G (eds) The computing neuron. Addison-Wesley, WorkinghamGoogle Scholar
- Tobin AE, Van Hooser SD, Calabrese RL (2006) Creation and reduction of a morphologically detailed model of a leech heart interneuron. J Neurophys 96:2107–2120Google Scholar
© Springer Science+Business Media New York 2015