Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Reduced Morphology Models

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6675-8_245

Synonyms

Definition

Reduced morphology models are simplified computational models obtained by collapsing the dendritic tree of a detailed neuron model, in such a way to preserve as much as possible the original membrane dynamics.

Detailed Description

Morphologically detailed neuron models are based on 3D anatomical cell reconstructions and describe how the spatial dendritic structure of a neuron together with the kinetic properties and distributions of ion channels and synaptic inputs contributes to the dynamics and functionality of a neuron. These compartmental neuron models are usually composed of hundreds of dendritic branches (Fig. 1) with nonlinear membrane properties.
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References

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Further Reading

  1. Migliore M, Shepherd GM (2005) Opinion: an integrated approach to classifying neuronal phenotypes. Nat Rev Neurosci 6:810–818PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Mathematics and ApplicationsUniversity of Naples Federico II, Complesso Universitario di Monte S. AngeloNaplesItaly
  2. 2.Department of NeurobiologyYale University School of MedicineNew HavenUSA
  3. 3.Institute of BiophysicsNational Research CouncilPalermoItaly