Delayed Rectifier and A-Type Potassium Channels
Voltage-gated potassium channels can be grouped into two broad categories: the delayed rectifiers and the “A-type” channels. Delayed rectifiers are named after their delay before activation commences following a voltage change and their contribution to rectification of the current-voltage relationship of cells once they are activated. Delayed rectifiers show little time-dependent inactivation. Inactivation is a process whereby the channels close without a change in the driving force. A-type potassium channels, in contrast, show prominent time and voltage-dependent inactivation. A-type channels may also activate with a delay. There are several approaches to modeling these channels. The roles that the different classes of channels may play in neuronal excitability depend on their interactions with other channels, the time course of voltage fluctuations in the cells, and their localization...
This work was supported by NIH/NIDCD grant DC004551 to PBM.
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