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X-Linked IAP

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Abstract

X-linked inhibitor of apoptosis protein (XIAP) is a member of the family of inhibitor of apoptosis proteins and part of the programmed cell death (apoptosis) pathway. Also known as BIRC4 (baculovirus IAP repeat-containing 4), XIAP resides in the cytoplasm. It acts as an inhibitor of caspases by directly binding to and inhibiting caspases 3, 7, and 9 and thus may inhibit both the intrinsic and extrinsic apoptosis pathways. Protein and RNA levels of XIAP can be measured but there are currently no FDA-approved tests for the measurement of XIAP in either tumor tissue or blood. XIAP is overexpressed in numerous malignancies. XIAP is currently being investigated as a predictive and prognostic tool in cancer and as a marker of resistance to cancer therapies. Restoration of apoptosis is an important priority for cancer drug development, thus targeting of XIAP is of critical significance. Second mitochondrial-derived activator of caspases (SMAC)-mimetics such as LCL-161 and antisense oligonucleotides such as AEG35156 inhibit XIAP and are being investigated in therapeutic clinical trials.

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Authors and Affiliations

  1. Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, A445 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH, 43210, USA

    Anne Noonan

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  1. Anne Noonan
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Correspondence to Anne Noonan .

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Editors and Affiliations

  1. Georgetown University Div. Hematology & Oncology, Washington, District of Columbia, USA

    John L. Marshall

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Noonan, A. (2013). X-Linked IAP. In: Marshall, J. (eds) Cancer Therapeutic Targets. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6613-0_68-4

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  • DOI: https://doi.org/10.1007/978-1-4614-6613-0_68-4

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6613-0

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