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PAP

Living reference work entry

Abstract

Prostatic acid phosphatase (PAP) is a 100 kDa glycoprotein synthesized by well-differentiated prostatic gland columnar epithelia and secreted in large quantity in seminal fluid (Hassan et al. 2010). PAP is present in elevated concentrations in the serum of men who have prostate cancer or other prostatic diseases (Hassan et al. 2010). The PAP gene is located along the long arm of chromosome 3 at locus 21 (3q21), and the protein product exists as intracellular, transmembrane, and secreted forms, with slightly different biochemical properties differentiating each of these (Hassan et al. 2010; Solin et al. 1990).

Keywords

Antigen-presenting cells (APCs) Castration-resistant prostate cancer (CRPC) Cytotoxic T-lymphocyte (CTL) activity Prostate cancer Prostatic acid phosphatase (PAP) Assessment Biology Clinical data Clinical utility of CRPC CTL activity Immunological strategies Multivariate analysis Preoperative levels Prognostic value Therapeutics Radioimmunoassay (RAI) 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Medical Oncology BranchNational Cancer InstituteBethesdaUSA

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