FGF-FGFR Signaling in Cancer

Living reference work entry

Abstract

Fibroblast growth factors (FGF) have pleiotropic roles in human development and metabolism, and FGF signaling through FGF receptors (FGFRs) has been implicated in a wide range of cancers. Extensive pre-clinical and clinical studies are currently underway to elucidate the therapeutic possibilities: monoclonal antibodies, ligand traps, heparanoids, and kinase inhibitors all have potential for the treatment of FGFR-driven cancers.

Keywords

Brivanib Dovitinib FGF receptor (FGFR) Fibroblast growth factor (FGF) Aberrant FGF Signaling A-loop tyrosine phosphorylation Core homology region CRKL ELISA Endocrine FGFs Exon 8 and exon 9 FGFR binding specificity FGFR dimerization FGFR1–3 genes FRS2α, 3 Immunohistochemical staining Mechanisms Overexpression Paracrine-acting FGF subfamilies Preclinical studies Prognostic markers Pyruvate kinase Role in cancer Single nucleotide polymorphisms (SNPs) Somatic mutations Subfamilies Therapy Palifermin 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of PharmacologyNYU Medical CenterNew YorkUSA
  2. 2.Internal MedicineNew York Presbyterian Hospital, Columbia University Medical CenterNew YorkUSA

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