C-Reactive Protein (CRP)
C-reactive protein (CRP) is an important protein of the acute-phase response, which is a nonspecific physiological and biochemical response to infection, inflammation, and tissue damage. Increases in CRP are found during infection, chronic inflammatory diseases, and following a myocardial infarction. Strenuous exercise and psychological stress can also induce increases in CRP, albeit to a lesser extent compared to the physiologically more traumatic events described above. Therefore, levels of CRP can be reflective of both acute and chronic inflammation (Gabay and Kushner 1999).
The CRP molecule consists of five calcium-binding nonglycosylated protomers in a pentameric symmetry. CRP is mainly produced by hepatocytes, even though other sources have also been reported. The production is stimulated by cytokines, which are released under the influence of the macrophages and monocytes at the site of the inflammation. Interleukin...