Encyclopedia of Behavioral Medicine

Living Edition
| Editors: Marc Gellman

C-Reactive Protein (CRP)

  • Jet Veldhuijzen van ZantenEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6439-6_446-2



C-reactive protein (CRP) is an important protein of the acute-phase response, which is a nonspecific physiological and biochemical response to infection, inflammation, and tissue damage. Increases in CRP are found during infection, chronic inflammatory diseases, and following a myocardial infarction. Strenuous exercise and psychological stress can also induce increases in CRP, albeit to a lesser extent compared to the physiologically more traumatic events described above. Therefore, levels of CRP can be reflective of both acute and chronic inflammation (Gabay and Kushner 1999).

The CRP molecule consists of five calcium-binding nonglycosylated protomers in a pentameric symmetry. CRP is mainly produced by hepatocytes, even though other sources have also been reported. The production is stimulated by cytokines, which are released under the influence of the macrophages and monocytes at the site of the inflammation. Interleukin...

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References and Further Reading

  1. Gabay, C., & Kushner, I. (1999). Acute-phase proteins and other systemic responses to inflammation. The New England Journal of Medicine, 340, 448–454.CrossRefGoogle Scholar
  2. Pepys, M. B., & Hirschfield, G. M. (2003). C-reactive protein: A critical update. Journal of Clinical Investigation, 111, 1805–1812.CrossRefGoogle Scholar
  3. Ridker, P. M. (2004). High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: From concept to clinical practice to clinical benefit. American Heart Journal, 148, S19–S26.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Sport and Exercise SciencesThe University of BirminghamEdgbaston, BirminghamUK

Section editors and affiliations

  • Anna C. Whittaker
    • 1
  1. 1.School of Sport, Exercise and Rehabilitation SciencesUniversity of BirminghamBirminghamUK