Endogenous opioids are neuropeptides with morphine-like activity that are naturally synthesized within the body. These neuropeptides have widespread distribution throughout the central and peripheral nervous systems, and various endocrine and other tissues. Opioids function as neurotransmitters and hormones, with a wide variety of biobehavioral effects in health and disease. Their effects on physiological and psychological responses to intense aversive and appetitive stimuli suggest potentially important roles in the etiology and treatment of self-regulatory disorders of appetite, affect, and adaptation to stress.
Classification of Opioid Peptides and Receptors
Endogenous opioids systems include several different neuroactive peptides that are linked, in turn, to a matrix of distinctive receptor systems. The opioid peptides are divided into basic...