Neurotensin (NT) is a multipotent 13-amino acid neuropeptide, originally found in the hypothalamus of cattle. It plays multiple physiological and pathological roles since it affects the nervous, cardiac, immune, and gastrointestinal systems, among others. NT is found in the central nervous system (CNS) and in the gastrointestinal system. It seems to play a role as an endogenous antipsychotic peptide and a role in colorectal cancer (Mustain et al. 2011). In cancer, NT and its receptor neurotensin receptor 1 have been found to play oncogenic roles. They mark prognosis in breast, lung, and head and neck cancers. Furthermore, NT seems to play a role in tumor growth as it acts as a growth factor as well as in promoting metastasis (Dupouy et al. 2011). These have important implications for drug development in the treatment of cancers as well. Dysregulation of NT also plays a role in schizophrenia and in the sensitizing reaction toward drugs, thus playing a possible role in...
KeywordsColorectal Cancer Mast Cell Neck Cancer Gastrointestinal System Acute Stress
References and Further Readings
- Dupouy, S., Mourra, N., Doan, V. K., Gompel, A., Alifano, M., & Forgez, P. (2011). The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers. Biochimie, 93, 1369–1378.CrossRefPubMedGoogle Scholar
- Pang, X., Alexacos, N., Letourneau, R., Seretakis D, D., Gao, W., Boucher, W., Cochrane, D. E., & Theoharides, T. C. (1998). A neurotensin receptor antagonist inhibits acute immobilization stress-induced cardiac mast cell degranulation, a corticotropin-releasing hormone-dependent process. Journal of Pharmacology and Experimental Therapy, 287, 307–314.Google Scholar