Encyclopedia of Behavioral Medicine

Living Edition
| Editors: Marc Gellman

Adhesion Molecules

  • Manjunath HarlapurEmail author
  • Daichi Shimbo
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6439-6_1254-2



Adhesion molecules are the protein molecules that are situated on the surface of the cells or the intracellular organelle.


The adhesion molecules attach to adjacent cells and help with binding with these cells or extracellular structures. There are several functions described like transmitting the information (cellular signaling pathways) to communicate between cells and within the cells. The adhesion molecules usually share a common basic structure that they have extracellular and intracellular domains that are connected to transcellular domain. This facilitates their function to act as messenger across the cellular membrane on either side.

Adhesion molecules are classified based on the function, structure, and location. Cadherins, integrins, selectins, and immunoglobulin (Ig)-related cell adhesion molecules (CAMS) are four major types of adhesion molecules. Brief summary of these molecules are described below.

The cadherins are...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Fuster, V., Lois, F., & Franco, M. (2010). Early identification of atherosclerotic disease by noninvasive imaging. Nature Reviews Cardiology, 7(6), 327–333.CrossRefGoogle Scholar
  2. Gahmberg, C. G., Valmu, L., Kotovuori, A., Kotovuori, P., Hilden, T. J., Fagerholm, S., & Tian, L. (1999). Leukocyte adhesion-an integrated molecular process at the leukocyte plasma membrane. Bioscience Reports, 19(4), 273–281.CrossRefGoogle Scholar
  3. Gonzalez-Amaro, R., & Sanchez-Madrid, F. (1999). Cell adhesion molecules: Selectins and integrins. Critical Reviews in Immunology, 19(5–6), 389–429.PubMedGoogle Scholar
  4. Worthylake, R. A., & Burridge, K. (2001). Leukocyte transendothelial migration: Orchestrating the underlying molecular machinery. Current Opinion in Cell Biology, 13(5), 569–577.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Center of Behavioral Cardiovascular Health, Division of General MedicineColumbia UniversityNew YorkUSA
  2. 2.Center for Behavioral Cardiovascular HealthColumbia UniversityNew YorkUSA

Section editors and affiliations

  • Linda C. Baumann
    • 1
  1. 1.School of NursingUniversity of Wisconsin-MadisonMadisonUSA