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Hematopoietic Stem Cell Transplantation

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Encyclopedia of Behavioral Medicine

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In general, hematological malignancies show good response to antineoplastic agents. However, less than half of patients with hematological malignancies can be cured with chemotherapy alone. Since some antineoplastic agents show linear dose-response relationship, increasing the dose of chemotherapy may increase the antineoplastic effects, but it is precluded by the adverse effects of antineoplastic agents, so-called dose-limiting toxicities. The dose-limiting toxicity of many antineoplastic agents is myelosuppression. Therefore, hematopoietic stem cell transplantation has been investigated to allow high-dose chemotherapy over the maximum tolerated dose by supporting the hematopoietic system with the infusion of hematopoietic stem cells from a donor (allogeneic transplantation) or the patients themselves (autologous transplantation). In addition to the effect of the high-dose chemotherapy, an immunological antineoplastic effect of donor cells, so-called...

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References and Further Readings

  • Forman SJ, Negrin RS, Antin JH, Appelbaum FR (2016) Thomas' hematopoietic cell transplantation. 5th ed, Wiley-Blackwell. ISBN: 1118416007.

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Authors and Affiliations

  1. Division of Hematology, Jichi Medical University Saitama Medical Center, Omiya-ku, Saitama, Japan

    Yoshinobu Kanda

Authors
  1. Yoshinobu Kanda
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Correspondence to Yoshinobu Kanda .

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Editors and Affiliations

  1. University of Miami School of Medicine, Miami, Florida, USA

    Marc Gellman

  2. Campbell University School of Pharmacy, Buies Creek, North Carolina, USA

    J. Rick Turner

Section Editor information

  1. The University of Tokyo, Department of Stress Sciences & Psychosomatic Medicine, Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan

    Kazuhiro Yoshiuchi

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Kanda, Y. (2018). Hematopoietic Stem Cell Transplantation. In: Gellman, M., Turner, J. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6439-6_1236-2

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  • DOI: https://doi.org/10.1007/978-1-4614-6439-6_1236-2

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6439-6

  • Online ISBN: 978-1-4614-6439-6

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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