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Immunosenescence

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References and Further Readings

  • Appay, V., & Sauce, D. (2014). Naive T cells: The crux of cellular immune aging? Experimental Gerontology, 54, 90–93.

    Article  CAS  PubMed  Google Scholar 

  • Briceno, O., Lissina, A., Wanke, K., Afonso, G., von Braun, A., Ragon, K., et al. (2016). Reduced naive CD8(+) T-cell priming efficacy in elderly adults. Aging Cell, 15(1), 14–21.

    Article  CAS  PubMed  Google Scholar 

  • Bueno, V., Sant’Anna, O. A., & Lord, J. M. (2014). Ageing and myeloid-derived suppressor cells: Possible involvement in immunosenescence and age-related disease. Age (Dordrecht, Netherlands), 36(6), 9729.

    Article  Google Scholar 

  • den Elzen, W. P., Vossen, A. C., Cools, H. J., Westendorp, R. G., Kroes, A. C., & Gussekloo, J. (2011). Cytomegalovirus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities. Vaccine, 29, 4869–4874.

    Article  Google Scholar 

  • Derhovanessian, E., Maier, A. B., Hahnel, K., Zelba, H., de Craen, A. J., Roelofs, H., et al. (2013). Lower proportion of naive peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people. Age (Dordrecht, Netherlands), 35(4), 1387–1399.

    Article  CAS  Google Scholar 

  • Ferrando-Martinez, S., Franco, J. M., Ruiz-Mateos, E., Hernandez, A., Ordonez, A., Gutierrez, E., & Leal, M. (2010). A reliable and simplified sj/beta-TREC ratio quantification method for human thymic output measurement. Journal of Immunological Methods, 352, 111–117.

    Article  CAS  PubMed  Google Scholar 

  • Franceschi, C., Bonafe, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E., & De Benedictis, G. (2000a). Inflamm-aging. An evolutionary perspective on immunosenescence. Annals of the New York Academy of Science, 908, 244–254.

    Article  CAS  Google Scholar 

  • Franceschi, C., Bonafe, M., & Valensin, S. (2000b). Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine, 18, 1717–1720.

    Article  CAS  PubMed  Google Scholar 

  • Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2015). Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine. Vaccine, 33, 1433–1439.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Geiger, H., de Haan, G., & Florian, M. C. (2013). The ageing haematopoietic stem cell compartment. Nature Reviews. Immunology, 13, 376–389.

    Article  CAS  PubMed  Google Scholar 

  • Giovannini, S., Onder, G., Liperoti, R., Russo, A., Carter, C., Capoluongo, E., et al. (2011). Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals. Journal of American Geriatric Society, 59(9), 1679–1685.

    Article  Google Scholar 

  • Goldeck, D., Oettinger, L., Janssen, N., Demuth, I., Steinhagen-Thiessen, E., & Pawelec, G. (2016). Cytomegalovirus infection minimally affects the frequencies of B-cell phenotypes in peripheral blood of younger and older adults. Gerontology, 62(3), 323–329.

    Article  CAS  PubMed  Google Scholar 

  • Gow, A. J., Firth, C. M., Harrison, R., Starr, J. M., Moss, P., & Deary, I. J. (2013). Cytomegalovirus infection and cognitive abilities in old age. Neurobiology of Aging, 34(7), 1846–1852.

    Article  PubMed  Google Scholar 

  • Haeseker, M. B., Pijpers, E., Dukers-Muijrers, N. H., Nelemans, P., Hoebe, C. J., Bruggeman, C. A., et al. (2013). Association of cytomegalovirus and other pathogens with frailty and diabetes mellitus, but not with cardiovascular disease and mortality in psycho-geriatric patients; a prospective cohort study. Immunity & Ageing, 10(1), 30.

    Article  Google Scholar 

  • Haq, K., & McElhaney, J. E. (2014). Immunosenescence: Influenza vaccination and the elderly. Current Opinion in Immunology, 29, 38–42.

    Article  CAS  PubMed  Google Scholar 

  • Hazeldine, J., & Lord, J. M. (2015). Innate immunesenescence: Underlying mechanisms and clinical relevance. Biogerontology, 16(2), 187–201.

    Article  CAS  PubMed  Google Scholar 

  • Jagger, A., Shimojima, Y., Goronzy, J. J., & Weyand, C. M. (2014). Regulatory T cells and the immune aging process: A mini-review. Gerontology, 60, 130–137.

    Article  CAS  PubMed  Google Scholar 

  • Olsson, J., Wikby, A., Johansson, B., Lofgren, S., Nilsson, B. O., & Ferguson, F. G. (2000). Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study. Mechanisms of Ageing & Development, 121, 187–201.

    Article  CAS  Google Scholar 

  • Ouyang, Q., Wagner, W. M., Voehringer, D., Wikby, A., Klatt, T., Walter, S., et al. (2003). Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Experimental Gerontology, 38(8), 911–920.

    Article  CAS  PubMed  Google Scholar 

  • Panda, A., Arjona, A., Sapey, E., Bai, F., Fikrig, E., Montgomery, R. R., et al. (2009). Human innate immunosenescence: Causes and consequences for immunity in old age. Trends in Immunology, 30(7), 325–333.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pawelec, G. (2014). Immunosenenescence: Role of cytomegalovirus. Experimental Gerontology, 54, 1–5.

    Article  CAS  PubMed  Google Scholar 

  • Peralbo, E., Alonso, C., & Solana, R. (2007). Invariant NKT and NKT-like lymphocytes: Two different T cell subsets that are differentially affected by ageing. Experimental Gerontology, 42(8), 703–708.

    Article  CAS  PubMed  Google Scholar 

  • Roberts-Thomson, I. C., Whittingham, S., Youngchaiyud, U., & Mackay, I. R. (1974). Ageing, immune response, and mortality. Lancet, 2, 368–370.

    Article  CAS  PubMed  Google Scholar 

  • Roux, A., Mourin, G., Larsen, M., Fastenackels, S., Urrutia, A., Gorochov, G., et al. (2013). Differential impact of age and cytomegalovirus infection on the gammadelta T cell compartment. Journal of Immunology, 191(3), 1300–1306.

    Article  CAS  Google Scholar 

  • Savva, G. M., Pachnio, A., Kaul, B., Morgan, K., Huppert, F. A., Brayne, C., & Moss, P. A. (2013). Cytomegalovirus infection is associated with increased mortality in the older population. Aging Cell, 12(3), 381–387.

    Article  CAS  PubMed  Google Scholar 

  • Schmitt, V., Rink, L., & Uciechowski, P. (2013). The Th17/Treg balance is disturbed during aging. Experimental Gerontology, 48, 1379–1386.

    Article  CAS  PubMed  Google Scholar 

  • Shearer, G. M. (1997). Th1/Th2 changes in aging. Mechanisms of Ageing and Development, 94, 1–5.

    Article  CAS  PubMed  Google Scholar 

  • Siegrist, C. A., & Aspinall, R. (2009). B-cell responses to vaccination at the extremes of age. Nature Reviews. Immunology, 9, 185–194.

    Article  CAS  PubMed  Google Scholar 

  • Solana, R., Campos, C., Pera, A., & Tarazona, R. (2014). Shaping of NK cell subsets by aging. Current Opinion in Immunology, 29, 56–61.

    Article  CAS  PubMed  Google Scholar 

  • van Lier, R. A., ten Berge, I. J., & Gamadia, L. E. (2003). Human CD8(+) T-cell differentiation in response to viruses. Nature Reviews. Immunology, 3, 931–939.

    Article  PubMed  Google Scholar 

  • Walford, R. L. (1969). The immunologic theory of aging. Copenhagen: Munksgaard.

    Google Scholar 

  • Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., et al. (2014). Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. Journal of Immunology, 192(5), 2143–2155.

    Article  CAS  Google Scholar 

  • Wikby, A., Maxson, P., Olsson, J., Johansson, B., & Ferguson, F. G. (1998). Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: The Swedish longitudinal OCTO-immune study. Mechanisms of Ageing & Development, 102, 187–198.

    Article  CAS  Google Scholar 

  • Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Lofgren, S., et al. (2005). An immune risk phenotype, cognitive impairment, and survival in very late life: Impact of allostatic load in Swedish octogenarian and nonagenarian humans. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 60(5), 556–565.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department for Health, University of Bath, Claverton Down, BA2 7AY, Bath, BANES, UK

    James Edward Turner

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  1. James Edward Turner
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Correspondence to James Edward Turner .

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Editors and Affiliations

  1. University of Miami School of Medicine, Miami, Florida, USA

    Marc Gellman

  2. Campbell University School of Pharmacy, Buies Creek, North Carolina, USA

    J. Rick Turner

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Turner, J.E. (2016). Immunosenescence. In: Gellman, M., Turner, J. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6439-6_101906-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6439-6_101906-1

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  • Online ISBN: 978-1-4614-6439-6

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