Encyclopedia of Behavioral Medicine

Living Edition
| Editors: Marc Gellman

Adipose Tissue Dysfunction

  • William Trim
  • Dylan Thompson
  • James E. TurnerEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6439-6_101903-1



The impairment of normal adipose tissue function, characterized by changes to the structure and cellular composition of the tissue microenvironment, resulting in abnormal secretions derived predominantly, but not exclusively, from adipocytes (i.e., fat cells) and localized immune cells. These changes can be instigated by energy imbalance and are commonly observed with aging and obesity. The result is expansion of abdominal subcutaneous and visceral (intra-abdominal) adipose tissue, but for women, especially, gluteofemoral (hip and legs) adipose stores. The broader consequences are local and systemic inflammation, impaired tissue-specific and whole-body insulin sensitivity, and poor metabolic control. Thus, adipose tissue dysfunction is implicated in the pathogenesis of type-II diabetes, hypertension, cancer, cognitive dysfunction, and atherosclerosis.


Background and Overview

Traditionally, adipose tissue was considered an...

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References and Further Reading

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Copyright information

© Springer Science+Business Media LLC 2018

Authors and Affiliations

  • William Trim
    • 1
  • Dylan Thompson
    • 1
  • James E. Turner
    • 1
    Email author
  1. 1.Department for HealthUniversity of BathBathUK

Section editors and affiliations

  • Anna C. Phillips
    • 1
  1. 1.School of Sport, Exercise & Rehabilitation SciencesUniversity of BirminghamBirminghamUK