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Striatal-Enriched Protein-Tyrosine Phosphatase (STEP)

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Encyclopedia of Signaling Molecules

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Synonyms

Neural-specific protein-tyrosine phosphatase; Protein-tyrosine phosphatase, non-receptor type 5 (striatum enriched); Protein-tyrosine phosphatase striatum enriched; PTPN5; PTPSTEP; STEP; Protein-tyrosine phosphatase non-receptor type 5

Historical Background

Protein-tyrosine phosphatases (PTPs) play a significant role in diverse signaling mechanisms ranging from cellular differentiation to synaptic plasticity (Paul and Lombroso 2003; Tonks 2006). STriatal-Enriched protein-tyrosine Phosphatase (STEP) is a brain-specific protein tyrosine phosphatase belonging to the non-receptor tyrosine phosphatase family. Although enriched in the striatum, it is also localized to neurons in the cortex, hippocampus, and related brain regions (Boulanger et al. 1995). Interestingly, it is absent in the cerebellum, where a highly related PTP, PTP-STEP-like, is present (Watanabe et al. 1998). STEP exists as two major isoforms, named after their mobility in SDS-PAGE and designated STEP61 and STEP46....

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Authors and Affiliations

  1. Child Study Center, Yale University, School of Medicine, New Haven, CT, 06473, USA

    Pradeep Kurup, Jian Xu, Manavi Chatterjee, Susan Goebel-Goody, Surojit Paul & Paul Lombroso

  2. Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA

    Surojit Paul

Authors
  1. Pradeep Kurup
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  2. Jian Xu
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  3. Manavi Chatterjee
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  4. Susan Goebel-Goody
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  5. Surojit Paul
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  6. Paul Lombroso
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Corresponding author

Correspondence to Paul Lombroso .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Kurup, P., Xu, J., Chatterjee, M., Goebel-Goody, S., Paul, S., Lombroso, P. (2016). Striatal-Enriched Protein-Tyrosine Phosphatase (STEP). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_630-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_630-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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