Historical Background
CCL3 was initially described in 1988, as a partially purified 8-kDa protein doublet from conditioned medium of endotoxin-stimulated mouse macrophages. In the view of its prominent proinflammatory chemotactic role, characterized both in vivo and in vitro at that time, this protein was denominated “macrophage inflammatory protein-1 alpha” (MIP-1α). Subsequently, a high nucleotide sequence similarity (69 %) was found between the murine MIP-1α cDNA and a reported human cDNA cloned from stimulated lymphocytes, initially called LD78α or GOS19, assuming to be the human counterpart to murine MIP-1α (Wolpe et al. 1988; Menten et al. 2002; Maurer and von Stebut 2004). Interestingly, human and murine MIP-1α have been independently isolated in many laboratories in relatively short time span and has been named differently by each group. Similarly, several other cytokines with chemotactic abilities were identified, leading to...
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Repeke, C.E., Garlet, T.P., Francisconi, C.F., Broll, D., Trombone, A.P.F., Garlet, G.P. (2016). CCL3. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_579-1
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DOI: https://doi.org/10.1007/978-1-4614-6438-9_579-1
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