Skip to main content
SpringerLink
Log in

CLEC4E

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 92 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Arumugam TV, Manzanero S, Furtado M, Biggins PJ, Hsieh YH, Gelderblom M, et al. An atypical role for the myeloid receptor Mincle in central nervous system injury. J Cereb Blood Flow Metab. 2016; doi:10.1177/0271678X16661201.

    Google Scholar 

  • Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, et al. Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice. Infect Immun. 2015;83:184–96. doi:10.1128/IAI.02500-14.

    Article  PubMed  Google Scholar 

  • Bowker N, Salie M, Schurz H, van Helden PD, Kinnear CJ, Hoal EG, et al. Polymorphisms in the pattern recognition receptor Mincle gene (CLEC4E) and association with tuberculosis. Lung. 2016; doi:10.1007/s00408-016-9915-y.

    PubMed  Google Scholar 

  • Bugarcic A, Hitchens K, Beckhouse AG, Wells CA, Ashman RB, Blanchard H. Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans. Glycobiology. 2008;18:679–85. doi:10.1093/glycob/cwn046.

    Article  CAS  PubMed  Google Scholar 

  • Comelli EM, Head SR, Gilmartin T, Whisenant T, Haslam SM, North SJ, et al. A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology. 2006;16:117–31. doi:10.1093/glycob/cwj048.

    Article  CAS  PubMed  Google Scholar 

  • de Rivero Vaccari JC, Brand 3rd FJ, Berti AF, OF A, Bullock MR, de Rivero Vaccari JP. Mincle signaling in the innate immune response after traumatic brain injury. J Neurotrauma. 2015;32:228–36. doi:10.1089/neu.2014.3436.

    Article  PubMed  Google Scholar 

  • Drummond RA, Saijo S, Iwakura Y, Brown GD. The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. Eur J Immunol. 2011;41:276–81. doi:10.1002/eji.201041252.

    Article  CAS  PubMed  Google Scholar 

  • Feinberg H, Jegouzo SA, Rowntree TJ, Guan Y, Brash MA, Taylor ME, et al. Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle. J Biol Chem. 2013;288:28457–65. doi:10.1074/jbc.M113.497149.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Flornes LM, Bryceson YT, Spurkland A, Lorentzen JC, Dissen E, Fossum S. Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Immunogenetics. 2004;56:506–17. doi:10.1007/s00251-004-0714-x.

    Article  CAS  PubMed  Google Scholar 

  • Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, et al. Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. Proc Natl Acad Sci U S A. 2013;110:17438–43. doi:10.1073/pnas.1312649110.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Greco SH, Mahmood SK, Vahle AK, Ochi A, Batel J, Deutsch M, et al. Mincle suppresses toll-like receptor 4 activation. J Leukoc Biol. 2016;100:185–94. doi:10.1189/jlb.3A0515-185R.

    Article  CAS  PubMed  Google Scholar 

  • Guo JP, Verdrengh M, Tarkowski A, Lange S, Jennische E, Lorentzen JC, et al. The rat antigen-presenting lectin-like receptor complex influences innate immunity and development of infectious diseases. Genes Immun. 2009;10:227–36. doi:10.1038/gene.2009.4.

    Article  CAS  PubMed  Google Scholar 

  • Hattori Y, Morita D, Fujiwara N, Mori D, Nakamura T, Harashima H, et al. Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin Mincle. J Biol Chem. 2014;289:15405–12. doi:10.1074/jbc.M114.566489.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He Y, Xu L, Li B, Guo ZN, Hu Q, Guo Z, et al. Macrophage-inducible C-type lectin/spleen tyrosine kinase signaling pathway contributes to neuroinflammation after subarachnoid hemorrhage in rats. Stroke. 2015;46:2277–86. doi:10.1161/STROKEAHA.115.010088.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heitmann L, Schoenen H, Ehlers S, Lang R, Holscher C. Mincle is not essential for controlling Mycobacterium tuberculosis infection. Immunobiology. 2013;218:506–16. doi:10.1016/j.imbio.2012.06.005.

    Article  CAS  PubMed  Google Scholar 

  • Huber A, Kallerup RS, Korsholm KS, Franzyk H, Lepenies B, Christensen D, et al. Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo. Innate Immun. 2016;22:405–18. doi:10.1177/1753425916651132.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Humphrey MB, Lanier LL, Nakamura MC. Role of ITAM-containing adapter proteins and their receptors in the immune system and bone. Immunol Rev. 2005;208:50–65. doi:10.1111/j.0105-2896.2005.00325.x.

    Article  CAS  PubMed  Google Scholar 

  • Ichioka M, Suganami T, Tsuda N, Shirakawa I, Hirata Y, Satoh-Asahara N, et al. Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes. 2011;60:819–26. doi:10.2337/db10-0864.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, et al. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med. 2009;206:2879–88. doi:10.1084/jem.20091750.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, et al. Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia. Cell Host Microbe. 2013;13:477–88. doi:10.1016/j.chom.2013.03.008.

    Article  CAS  PubMed  Google Scholar 

  • Jacobsen KM, Keiding UB, Clement LL, Schaffert ES, Rambaruth ND, Johannsen M, et al. The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle. Medchemcommun. 2015;6:647–52. doi:10.1039/c4md00512k.

    Article  CAS  Google Scholar 

  • Jegouzo SA, Harding EC, Acton O, Rex MJ, Fadden AJ, Taylor ME, et al. Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate. Glycobiology. 2014;24:1291–300. doi:10.1093/glycob/cwu072.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kataoka H, Kono H, Patel Z, Kimura Y, Rock KL. Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses. PLoS One. 2014;9:e104741. doi:10.1371/journal.pone.0104741.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kawata K, Illarionov P, Yang GX, Kenny TP, Zhang W, Tsuda M, et al. Mincle and human B cell function. J Autoimmun. 2012;39:315–22. doi:10.1016/j.jaut.2012.04.004.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khajoee V, Saito M, Takada H, Nomura A, Kusuhara K, Yoshida SI, et al. Novel roles of osteopontin and CXC chemokine ligand 7 in the defence against mycobacterial infection. Clin Exp Immunol. 2006;143:260–8. doi:10.1111/j.1365-2249.2005.02985.x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kiyotake R, Oh-Hora M, Ishikawa E, Miyamoto T, Ishibashi T, Yamasaki S. Human Mincle binds to cholesterol crystals and triggers innate immune responses. J Biol Chem. 2015;290:25322–32. doi:10.1074/jbc.M115.645234.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kodar K, Eising S, Khan AA, Steiger S, Harper JL, Timmer MS, et al. The uptake of trehalose glycolipids by macrophages is independent of Mincle. ChemBioChem. 2015;16:683–93. doi:10.1002/cbic.201402506.

    Article  CAS  PubMed  Google Scholar 

  • Lee WB, Kang JS, Yan JJ, Lee MS, Jeon BY, Cho SN, et al. Neutrophils promote Mycobacterial trehalose dimycolate-induced lung inflammation via the Mincle pathway. PLoS Pathog. 2012;8:e1002614. doi:10.1371/journal.ppat.1002614.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee WB, Kang JS, Choi WY, Zhang Q, Kim CH, Choi UY, et al. Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Nat Commun. 2016;7:11322. doi:10.1038/ncomms11322.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lobato-Pascual A, Saether PC, Fossum S, Dissen E, Daws MR. Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcepsilonRI-gamma. Eur J Immunol. 2013;43:3167–74. doi:10.1002/eji.201343752.

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, et al. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol. 1999;163:5039–48.

    CAS  PubMed  Google Scholar 

  • McKimmie CS, Roy D, Forster T, Fazakerley JK. Innate immune response gene expression profiles of N9 microglia are pathogen-type specific. J Neuroimmunol. 2006;175:128–41. doi:10.1016/j.jneuroim.2006.03.012.

    Article  CAS  PubMed  Google Scholar 

  • Miyake Y, Masatsugu OH, Yamasaki S. C-type lectin receptor MCL facilitates Mincle expression and signaling through complex formation. J Immunol. 2015;194:5366–74. doi:10.4049/jimmunol.1402429.

    Article  CAS  PubMed  Google Scholar 

  • Nakamura N, Shimaoka Y, Tougan T, Onda H, Okuzaki D, Zhao H, et al. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. DNA Res. 2006;13:169–83. doi:10.1093/dnares/dsl006.

    Article  CAS  PubMed  Google Scholar 

  • Patin EC, Willcocks S, Orr S, Ward TH, Lang R, Schaible UE. Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate Immun. 2016;22:181–5. doi:10.1177/1753425916636671.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, et al. The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response. PLoS One. 2015;10:e0117022. doi:10.1371/journal.pone.0117022.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rambaruth ND, Jegouzo SA, Marlor H, Taylor ME, Drickamer K. Mouse mincle: characterization as a model for human mincle and evolutionary implications. Molecules. 2015;20:6670–82. doi:10.3390/molecules20046670.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ribbing C, Engblom C, Lappalainen J, Lindstedt K, Kovanen PT, Karlsson MA, et al. Mast cells generated from patients with atopic eczema have enhanced levels of granule mediators and an impaired Dectin-1 expression. Allergy. 2011;66:110–9. doi:10.1111/j.1398-9995.2010.02437.x.

    Article  CAS  PubMed  Google Scholar 

  • Richardson MB, Torigoe S, Yamasaki S, Williams SJ. Mycobacterium tuberculosis beta-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships. Chem Commun (Camb). 2015;51:15027–30. doi:10.1039/c5cc04773k.

    Article  CAS  Google Scholar 

  • Rosseau S, Hocke A, Mollenkopf H, Schmeck B, Suttorp N, Kaufmann SH, et al. Comparative transcriptional profiling of the lung reveals shared and distinct features of Streptococcus pneumoniae and influenza A virus infection. Immunology. 2007;120:380–91. doi:10.1111/j.1365-2567.2006.02514.x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ryll R, Kumazawa Y, Yano I. Immunological properties of trehalose dimycolate (cord factor) and other mycolic acid-containing glycolipids – a review. Microbiol Immunol. 2001;45:801–11.

    Article  CAS  PubMed  Google Scholar 

  • Saravanan C, Cao Z, Head SR, Panjwani N. Analysis of differential expression of glycosyltransferases in healing corneas by glycogene microarrays. Glycobiology. 2010;20:13–23. doi:10.1093/glycob/cwp133.

    Article  CAS  PubMed  Google Scholar 

  • Schoenen H, Bodendorfer B, Hitchens K, Manzanero S, Werninghaus K, Nimmerjahn F, et al. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol. 2010;184:2756–60. doi:10.4049/jimmunol.0904013.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schoenen H, Huber A, Sonda N, Zimmermann S, Jantsch J, Lepenies B, et al. Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPbeta and HIF1alpha. J Immunol. 2014;193:3664–75. doi:10.4049/jimmunol.1301593.

    Article  CAS  PubMed  Google Scholar 

  • Seifert L, Werba G, Tiwari S, Giao Ly NN, Alothman S, Alqunaibit D, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016;532:245–9. doi:10.1038/nature17403.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sharma A, Steichen AL, Jondle CN, Mishra BB, Sharma J. Protective role of Mincle in bacterial pneumonia by regulation of neutrophil mediated phagocytosis and extracellular trap formation. J Infect Dis. 2014;209:1837–46. doi:10.1093/infdis/jit820.

    Article  CAS  PubMed  Google Scholar 

  • Stocker BL, Khan AA, Chee SH, Kamena F, Timmer MS. On one leg: trehalose monoesters activate macrophages in a Mincle-dependant manner. Chem BiChem. 2014;15:382–8. doi:10.1002/cbic.201300674.

    CAS  Google Scholar 

  • Suzuki Y, Nakano Y, Mishiro K, Takagi T, Tsuruma K, Nakamura M, et al. Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke. Sci Report. 2013;3:3177. doi:10.1038/srep03177.

    Google Scholar 

  • Tamura T, Thotakura P, Tanaka TS, Ko MS, Ozato K. Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood. 2005;106:1938–47. doi:10.1182/blood-2005-01-0080.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tanaka M, Ikeda K, Suganami T, Komiya C, Ochi K, Shirakawa I, et al. Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Nat Commun. 2014;5:4982. doi:10.1038/ncomms5982.

    Article  CAS  PubMed  Google Scholar 

  • Toyonaga K, Miyake Y, Yamasaki S. Characterization of the receptors for mycobacterial cord factor in Guinea pig. PLoS One. 2014;9:e88747. doi:10.1371/journal.pone.0088747.

    Article  PubMed  PubMed Central  Google Scholar 

  • van der Peet PL, Gunawan C, Torigoe S, Yamasaki S, Williams SJ. Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle. Chem Commun (Camb). 2015;51:5100–3. doi:10.1039/c5cc00085h.

    Article  Google Scholar 

  • Vijayan D, Radford KJ, Beckhouse AG, Ashman RB, Wells CA. Mincle polarizes human monocyte and neutrophil responses to Candida albicans. Immunol Cell Biol. 2012;90:889–95. doi:10.1038/icb.2012.24.

    Article  CAS  PubMed  Google Scholar 

  • Wells CA, Salvage-Jones JA, Li X, Hitchens K, Butcher S, Murray RZ, et al. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol. 2008;180:7404–13.

    Article  CAS  PubMed  Google Scholar 

  • Wevers BA, Kaptein TM, Zijlstra-Willems EM, Theelen B, Boekhout T, Geijtenbeek TB, et al. Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. Cell Host Microbe. 2014;15:494–505. doi:10.1016/j.chom.2014.03.008.

    Article  CAS  PubMed  Google Scholar 

  • Wuthrich M, Wang H, Li M, Lerksuthirat T, Hardison SE, Brown GD, et al. Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition. Eur J Immunol. 2015;45:2542–52. doi:10.1002/eji.201545591.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol. 2008;9:1179–88. doi:10.1038/ni.1651.

    Article  CAS  PubMed  Google Scholar 

  • Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, et al. C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc Natl Acad Sci U S A. 2009;106:1897–902. doi:10.1073/pnas.0805177106.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao XQ, Zhu LL, Chang Q, Jiang C, You Y, Luo T, et al. C-type lectin receptor dectin-3 mediates trehalose 6,6′-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-kappaB activation. J Biol Chem. 2014;289:30052–62. doi:10.1074/jbc.M114.588574.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Cellular and Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, OX3 7BN, UK

    Michael E. Reschen, Anita R. Mistry & Christopher A. O’Callaghan

Authors
  1. Michael E. Reschen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anita R. Mistry
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christopher A. O’Callaghan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christopher A. O’Callaghan .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Reschen, M.E., Mistry, A.R., O’Callaghan, C.A. (2016). CLEC4E. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_571-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_571-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation