Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

CLEC4E

  • Michael E. Reschen
  • Anita R. Mistry
  • Christopher A. O’Callaghan
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_571-1

Synonyms

Historical Background

CLEC4E is a type 2 transmembrane receptor that is a member of the C-type lectin family of immune receptors and possesses a carbohydrate-recognition domain in its extracellular region. It was originally identified as a downstream transcriptional target of CCAAT/enhancer-binding protein beta in mouse macrophages and termed macrophage-inducible protein – Mincle (Matsumoto et al. 1999). The finding 10 years later that CLEC4E is a key receptor for the mycobacterial cell wall component, trehalose dimycolate, led to a surge in interest in the role of CLEC4E in controlling mycobacterial infection and in its ligands as potential vaccine adjuvants (Ishikawa et al. 2009). Furthermore, data has emerged implicating CLEC4E in the immune response to fungal infections...

Keywords

Mycobacterial Infection Mycolic Acid Malassezia Species Sugar Binding Site Trehalose Dimycolate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Michael E. Reschen
    • 1
  • Anita R. Mistry
    • 1
  • Christopher A. O’Callaghan
    • 1
  1. 1.Centre for Cellular and Molecular Physiology, Nuffield Department of Clinical MedicineUniversity of OxfordHeadington, OxfordUK