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VRK2

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Encyclopedia of Signaling Molecules

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Synonyms

Vaccinia-related kinase 2; Vaccinia virus B1R-related kinase 2; VRK2; VRK-2

Historical Background

Mammalian VRK (vaccinia-related kinases) were originally identified as two human EST, VRK1 and VRK2, expressed in proliferating cell lines and regenerating liver. These EST have homology to the catalytic region of the B1R kinase of vaccinia virus (Nezu et al. 1997) that is expressed early in viral infection and is required for viral DNA replication. These VRK proteins were classified as a new group of Ser-Thr kinases in the human kinome diverging very early from the same branch that led to casein kinase I (CK1) (Manning et al. 2002). This family has only one ortholog gene in invertebrates, such as C. elegans and Drosophila melanogaster, and is not present in yeast (Klerkx et al. 2009).

VRK2 Gene and Expression

The human VRK2gene is located in chromosome 2p16.1 and generates two messages by alternative splicing. Their translation generates two protein isoforms, VRK2A (also known...

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References

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Authors and Affiliations

  1. Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Salamanca, Campus Miguel de Unamuno, E-37007, Salamanca, Spain

    Diana M. Monsalve, Sandra Blanco, Isabel F. Fernández, Marta Vázquez-Cedeira & Pedro A. Lazo

  2. CSIC-Universidad de Salamanca, Instituto de Biología Molecular y Celular del Cáncer, Campus Miguel de Unamuno s/n, E-37007, Salamanca, Spain

    Pedro A. Lazo

  3. Instituto de Investigación Biomédica de Salamanca (IBSAL), Hospital Universitario de Salamanca, Salamanca, Spain

    Pedro A. Lazo

Authors
  1. Diana M. Monsalve
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  2. Sandra Blanco
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  3. Isabel F. Fernández
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  4. Marta Vázquez-Cedeira
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  5. Pedro A. Lazo
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Corresponding author

Correspondence to Pedro A. Lazo .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Monsalve, D.M., Blanco, S., Fernández, I.F., Vázquez-Cedeira, M., Lazo, P.A. (2017). VRK2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_562-2

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_562-2

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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Chapter history

  1. Latest

    VRK2
    Published:
    22 February 2017

    DOI: https://doi.org/10.1007/978-1-4614-6438-9_562-2

  2. Original

    VRK2
    Published:
    27 October 2016

    DOI: https://doi.org/10.1007/978-1-4614-6438-9_562-1

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