Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi


  • João Gonçalves
  • Helena Soares
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_551-1


Historical Background

The major microtubule-organizing center in animal cells is the centrosome which consists of a pair of centrioles surrounded by the pericentriolar matrix. In interphase cells, centrosomes nucleate and organize the microtubule cytoskeleton and are usually maintained at the cell center in close association with the nucleus (Bettencourt-Dias and Glover 2007). This association constitutes a primordial axis of cytoplasmic compartment organization and organelle positioning (e.g., ER and Golgi apparatus). Centrosomes are also involved in mitotic spindle formation, and an aberrant centrosome number has been linked to multipolar spindles and to cancer cells. In the last years, the ability of centrosomes to become basal bodies and assemble cilia emerged also as a critical function (Bettencourt-Dias and Glover 2007). Cilia are now established as having important roles as movement generating and sensory organelles being essential for...


Retinitis Pigmentosa Basal Body Centrosomal Protein Tubulin Heterodimers Spindle Midzone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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  1. André J, Harrison S, Towers K, Qi X, Vaughan S, McKean PG, Ginger ML. The tubulin cofactor C family member TBCCD1 orchestrates cytoskeletal filament formation. J Cell Sci. 2013;126(Pt 23):5350–6. doi:10.1242/jcs.136515.CrossRefPubMedGoogle Scholar
  2. Archambault V, Zhao X, White-Cooper H, Carpenter ATC, Glover DM. Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinase. PLoS Genet. 2007;3(11):e200.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Bartolini F, Bhamidipati A, Thomas S, Schwahn U, Lewis SA, Cowan NJ. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. J Biol Chem. 2002;277:14629–34.CrossRefPubMedGoogle Scholar
  4. Bettencourt-Dias M, Glover DM. Centrosome biogenesis and function: centrosomics brings new understanding. Nat Rev Mol Cell Biol. 2007;8:451–63.CrossRefPubMedGoogle Scholar
  5. Buch C, Lindberg R, Figueroa R, Gudise S, Onischenko E, Hallberg E. An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells. J Cell Sci. 2009;122:2100–7.CrossRefPubMedGoogle Scholar
  6. Burakov AV, Nadezhdina ES. Association of nucleus and centrosome: magnet or velcro? J Cell Biol Int. 2013;37:95–104. doi:10.1002/cbin.10016.CrossRefGoogle Scholar
  7. Chevrier V, Piel M, Collomb N, Saoudi Y, Frank R, Paintrand M, Narumiya S, Bornens M, Job D. The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J Cell Biol. 2002;157:807–17.CrossRefPubMedPubMedCentralGoogle Scholar
  8. Cuvillier A, Redon F, Antoine JC, Chardin P, DeVos T, Merlin G. LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity. J Cell Sci. 2000;113:2065–74.PubMedGoogle Scholar
  9. Feldman JL, Marshall WF. ASQ2 Encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation. Curr Biol. 2009;19:1238–43.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Fontalba A, Paciucci R, Avila J, Zabala JC. Incorporation of tubulin subunits into dimers requires GTP hydrolysis. J Cell Sci. 1993;106:627–32.PubMedGoogle Scholar
  11. Gonçalves J, Nolasco S, Nascimento R, Lopez Fanarraga M, Zabala JC, Soares H. TBCCD1, a new centrosomal protein is required for centrosome and Golgi apparatus positioning. EMBO Rep. 2010;11:194–200.CrossRefPubMedPubMedCentralGoogle Scholar
  12. Lopez-Fanarraga M, Avila J, Guasch A, Coll M, Zabala JC. Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics. J Struct Biol. 2001;135:219–29.CrossRefPubMedGoogle Scholar
  13. Nigg EA, Raff JW. Centrioles, centrosomes and cilia in health and disease. Cell. 2009;139:663–78.CrossRefPubMedGoogle Scholar
  14. Pouthas F, Girard P, Lecaudey V, Ly TB, Gilmour D, Boulin C, Pepperkok R, Reynaud EG. In migrating cells, the Golgi complex and the position of the centrosome depend on geometrical constraints of the substratum. J Cell Sci. 2008;121:2406–14.CrossRefPubMedGoogle Scholar
  15. Schrick JJ, Vogel P, Abuin A, Hampton B, Rice DS. ADP-ribosylation factor-like 3 is involved in kidney and photoreceptor development. Am J Pathol. 2006;168:1288–98.CrossRefPubMedPubMedCentralGoogle Scholar
  16. Schwahn U, Lenzner S, Dong J, Feil S, Hinzmann B, van Duijnhoven G, Kirschner R, Hemberger M, Bergen AA, Rosenberg T, Pinckers AJ, Fundele R, Rosenthal A, Cremers FP, Ropers HH, Berger W. Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat Genet. 1998;19:327–32.CrossRefPubMedGoogle Scholar
  17. Schwarz N, Hardcastle AJ, Cheetham ME. Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins. Vis Res. 2012;75:2–4. doi:10.1016/j.visres.2012.07.016.CrossRefPubMedGoogle Scholar
  18. Tian G, Bhamidipati A, Cowan NJ, Lewis SA. Tubulin folding cofactors as GTPase-ctivating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer. J Biol Chem. 1999;274:24054–8.CrossRefPubMedGoogle Scholar
  19. Veltel S, Gasper R, Eisenacher E, Wittinghofer A. The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol. 2008;15:373–80.CrossRefPubMedGoogle Scholar
  20. Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA. Arl2 and Arl3 regulate different microtubule-dependent processes. Mol Biol Cell. 2006;17:2476–87.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Centro de Química e Bioquímica, Faculdade de CiênciasUniversidade de LisboaLisboaPortugal
  2. 2.Lunenfeld-Tanenbaum Research InstituteTorontoCanada
  3. 3.Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de LisboaLisboaPortugal