Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

TBCCD1

  • João Gonçalves
  • Helena Soares
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_551-1

Synonyms

Historical Background

The major microtubule-organizing center in animal cells is the centrosome which consists of a pair of centrioles surrounded by the pericentriolar matrix. In interphase cells, centrosomes nucleate and organize the microtubule cytoskeleton and are usually maintained at the cell center in close association with the nucleus (Bettencourt-Dias and Glover 2007). This association constitutes a primordial axis of cytoplasmic compartment organization and organelle positioning (e.g., ER and Golgi apparatus). Centrosomes are also involved in mitotic spindle formation, and an aberrant centrosome number has been linked to multipolar spindles and to cancer cells. In the last years, the ability of centrosomes to become basal bodies and assemble cilia emerged also as a critical function (Bettencourt-Dias and Glover 2007). Cilia are now established as having important roles as movement generating and sensory organelles being essential for...

Keywords

Retinitis Pigmentosa Basal Body Centrosomal Protein Tubulin Heterodimers Spindle Midzone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Centro de Química e Bioquímica, Faculdade de CiênciasUniversidade de LisboaLisboaPortugal
  2. 2.Lunenfeld-Tanenbaum Research InstituteTorontoCanada
  3. 3.Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de LisboaLisboaPortugal