Skip to main content
SpringerLink
Log in

RASA1

  • Living reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

  • 48 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Bernards A. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim Biophys Acta. 2003;1603(2):47–82.

    CAS  PubMed  Google Scholar 

  • Boon LM, Mulliken JB, et al. RASA1: variable phenotype with capillary and arteriovenous malformations. Curr Opin Genet Dev. 2005;15(3):265–9.

    Article  CAS  PubMed  Google Scholar 

  • Burrows PE, Gonzalez-Garay ML, et al. Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man. Proc Natl Acad Sci USA. 2013;110(21):8621–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ekman S, Thuresson ER, et al. Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding. Oncogene. 1999;18(15):2481–8.

    Article  CAS  PubMed  Google Scholar 

  • Friedman E, Gejman PV, et al. Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours. Nat Genet. 1993;5(3):242–7.

    Article  CAS  PubMed  Google Scholar 

  • Gideon P, John J, et al. Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity. Mol Cell Biol. 1992;12(5):2050–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Giglione C, Gonfloni S, et al. Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm. Eur J Biochem. 2001;268(11):3275–83.

    Article  CAS  PubMed  Google Scholar 

  • Henkemeyer M, Rossi DJ, et al. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature. 1995;377(6551):695–701.

    Article  CAS  PubMed  Google Scholar 

  • Iwashita S, Song SY. RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions. Mol BioSyst. 2008;4(3):213–22.

    Article  CAS  PubMed  Google Scholar 

  • Khalil H, Loukili N, et al. The caspase-3-p120-RasGAP module generates a NF-kappaB repressor in response to cellular stress. J Cell Sci. 2015;128(18):3502–13.

    Article  CAS  PubMed  Google Scholar 

  • Kulkarni SV, Gish G, et al. Role of p120 Ras-GAP in directed cell movement. J Cell Biol. 2000;149(2):457–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lapinski PE, Qiao Y, et al. A role for p120 RasGAP in thymocyte positive selection and survival of naive T cells. J Immunol. 2011;187(1):151–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lapinski PE, Kwon S, et al. RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest. 2012;122(2):733–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lubeck BA, Lapinski PE, et al. Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation. Am J Pathol. 2014;184(12):3163–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lubeck BA, Lapinski PE, et al. Cutting edge: codeletion of the Ras GTPase-activating proteins (RasGAPs) neurofibromin 1 and p120 RasGAP in T cells results in the development of T cell acute lymphoblastic leukemia. J Immunol. 2015;195(1):31–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Macmurdo CF, Wooderchak-Donahue W, et al. RASA1 somatic mutation and variable expressivity in capillary malformation/arteriovenous malformation (CM/AVM) syndrome. Am J Med Genet A. 2016;170(6):1450–4.

    Article  CAS  PubMed  Google Scholar 

  • Margolis B, Li N, et al. The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J. 1990;9(13):4375–80.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marshall MS, Hill WS, et al. A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity. EMBO J. 1989;8(4):1105–10.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Revencu N, Boon LM, et al. Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. Hum Mutat. 2008;29(7):959–65.

    Article  CAS  PubMed  Google Scholar 

  • Revencu N, Boon LM, et al. RASA1 mutations and associated phenotypes in 68 families with capillary malformation-arteriovenous malformation. Hum Mutat. 2013;34(12):1632–41.

    Article  CAS  PubMed  Google Scholar 

  • Scheffzek K, Ahmadian MR, et al. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science. 1997;277(5324):333–8.

    Article  CAS  PubMed  Google Scholar 

  • Takai Y, Sasaki T, et al. Small GTP-binding proteins. Physiol Rev. 2001;81(1):153–208.

    CAS  PubMed  Google Scholar 

  • Trahey M, McCormick F. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science. 1987;238(4826):542–5.

    Article  CAS  PubMed  Google Scholar 

  • Trahey M, Wong G, et al. Molecular cloning of two types of GAP complementary DNA from human placenta. Science. 1988;242(4886):1697–700.

    Article  CAS  PubMed  Google Scholar 

  • Vogel US, Dixon RA, et al. Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature. 1988;335(6185):90–3.

    Article  CAS  PubMed  Google Scholar 

  • Wennerberg, K., K. L. Rossman, et al.. The Ras superfamily at a glance. J Cell Sci. 2005;118 Pt 5:843–6.

    Google Scholar 

  • Yang JY, Walicki J, et al. Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157. Mol Biol Cell. 2005;16(8):3511–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Michigan, Medical School, 1150 West Medical Center, Ann Arbor, 48109-0620, MI, USA

    Philip E. Lapinski & Philip D. King

Authors
  1. Philip E. Lapinski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Philip D. King
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Philip D. King .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Lapinski, P.E., King, P.D. (2016). RASA1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_534-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_534-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation