The tyrosine kinase ACK1 (activated Cdc42Hs-associated kinase 1) was first identified as a specific target of the small GTPase Cdc42 (Manser et al. 1993). ACK1, a related tyrosine kinase Tnk1, and the nontyrosine kinase protein Mig6 (Gene 33/receptor-associated late transducer) constitute a family of proteins with conserved domain structures. In addition to the kinase catalytic domain, various domains and amino acid sequence motifs, which are responsible for the interaction with diverse signal transducing proteins, are found in ACK1 (Fig. 1). Several types of splice variants (including a protein previously designated ACK2 (activated Cdc42Hs-associated kinase 2)) are present. Two orthologs of the mammalian ACK1 gene, DACK and DPR2, exist in the Drosophila melanogaster genome. In Caenorhabditis elegans, two orthologs encode ACK family protein tyrosine...
KeywordsEpidermal Growth Factor Receptor Androgen Receptor Epidermal Growth Factor Stimulation Kinase Catalytic Domain Sterile Alpha Motif Domain
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- Linderoth E, Pilia G, Mahajan NP, Ferby I. Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death. J Biol Chem. 2013;288:32922–31.CrossRefPubMedPubMedCentralGoogle Scholar
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