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P2Y14 Receptor

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

GPR105; KIAA0001

Historical Background

Extracellular purine and pyrimidine nucleotides act as signaling molecules through the activation of P2X ion channels and P2Y G protein-coupled receptors (GPCRs) (Abbracchio et al. 2006). Among the eight members of the P2Y receptor family, four respond to extracellular uracil nucleotides: P2Y2, P2Y4, P2Y6, and P2Y14 receptors. None of the P2X ion channels are substantially activated by uracil nucleotides.

P2Y2, P2Y4, and P2Y6 receptors belong to the P2Y1-like subgroup of Gq-coupled receptors, and the P2Y14 receptor belongs to the P2Y12-like subgroup that couples to G protein αi to inhibit adenylyl cyclase. The P2Y14 receptor is distributed in various tissues, that is, placenta, adipose, stomach, intestine, spleen, thymus, lung, heart, mast cells, and discrete brain regions (Freeman et al. 2001; Harden et al. 2010). It is activated by uridine-5′-diphosphoglucose (UDPG, 1, Fig. 1), other endogenous UDP-sugars, and uridine-5′-diphosphate...

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Authors and Affiliations

  1. Laboratory of Bioorganic Chemistry & Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, Bethesda, MD, 20892-0810, USA

    Kenneth A. Jacobson, Ramachandran Balasubramanian, Antonella Ciancetta & Zhan-Guo Gao

Authors
  1. Kenneth A. Jacobson
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  2. Ramachandran Balasubramanian
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  3. Antonella Ciancetta
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  4. Zhan-Guo Gao
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Corresponding author

Correspondence to Kenneth A. Jacobson .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Jacobson, K.A., Balasubramanian, R., Ciancetta, A., Gao, ZG. (2016). P2Y14 Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_471-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_471-1

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  • Online ISBN: 978-1-4614-6438-9

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