Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

ITPK1 (Inositol Tetrakisphosphate 1-Kinase)

  • Yixing Zhou
  • Tobias M. H. Schenk
  • Stephen B. Shears
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_457-1


Historical Background: Evolution of the Concept that ITPK1 Is a Cell-Signaling Enzyme

A 6-kinase activity that phosphorylates Ins(1,3,4)P3 to Ins(1,3,4,6)P4 (EC was originally described in 1987 by two separate groups working independently (Balla et al. 1987; Shears et al. 1987). The gene encoding the 46 kDa 6-kinase was cloned almost 10 years later (Wilson and Majerus 1996). The enzyme also has a less active 5-kinase activity towards Ins(1,3,4)P3 (Shears 1989; Wilson and Majerus 1996), and so was generally referred to as an “inositol 1,3,4-trisphosphate 5/6-kinase.” This prompted the HGNC (the HUGO Gene Nomenclature Committee; http://www.genenames.org/) to accept that the corresponding gene could be named as ITPK1. Subsequently, the enzyme was found to also add a 1-phosphate to Ins(3,4,5,6)P4 (Yang and Shears 2000). This was a particularly significant observation from a cell signaling perspective, as Ins(3,4,5,6)P4 had...


Inositol Phosphate Aortic Smooth Muscle Cell Chloride Current Chloride Conductance Insulin Granule 
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Authors and Affiliations

  • Yixing Zhou
    • 1
  • Tobias M. H. Schenk
    • 2
  • Stephen B. Shears
    • 3
  1. 1.ICON PLC79 TW Alexander Drive 4401 Research CommonsSuite 300DurhamUSA
  2. 2.Laboratory of Signal Transduction, Inositol Signaling SectionNational Institute of Environmental Health Sciences (NIEHS/NIH)KoelnGermany
  3. 3.Laboratory of Signal Transduction, Inositol Signaling SectionNational Institute of Environmental Health Sciences (NIEHS/NIH)Research Triangle ParkUSA