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Encyclopedia of Signaling Molecules pp 1–9Cite as

CD38

  • Living reference work entry
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Synonyms

ADP-ribosyl cyclase; Cyclic ADP-ribose hydrolase; NAD+ and NAD(P)+ nucleosidase; p45 antigen; T10 cell differentiation antigen, identified by monoclonal antibody OKT10, HB-7

Historical Background

CD38, as many molecules described in this encyclopedia, was described and characterized in the period 1980–1990, using a mouse monoclonal antibody recognizing human CD38 (mAb) (OKT-10) developed by Ellie L. Reinherz et al. (1980). Through the use of this and many other mAbs, it was determined that CD38 is expressed in activated human T cells, plasma cells, and several lymphoid and myeloid cells as well as many cell malignancies. CD38 was rediscovered in mice by the mAb NIM-R5 developed by Mike Parkhouse and his group at the National Institute of Medical Research, Mill Hill, London, UK (Santos-Argumedo et al. 1993), and in conjunction with other tools, allowed its biochemical and biological characterization. Despite being a useful marker, very little was known about its function. The...

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References

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Authors and Affiliations

  1. Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados (CINVESTAV-IPN), Av. IPN # 2508, Col. Zacatenco, 07360, Mexico City, Mexico

    Leopoldo Santos-Argumedo

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  1. Leopoldo Santos-Argumedo
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Correspondence to Leopoldo Santos-Argumedo .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Santos-Argumedo, L. (2016). CD38. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_278-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_278-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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