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Lysyl Oxidase

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

Synonyms

LO; Lox; LOX; Rrg

Historical Background

The extracellular matrix (ECM) provides a structural and signaling environment that determines cell fate, adhesion, proliferation, differentiation, migration, and communication during development, tissue maintenance and repair, and pathological processes. The composition of the ECM is unique in each organ and consistently includes various types of collagens, noncollagenous glycoproteins, and a range of enzymes essential for ECM assembly and maintenance including lysyl oxidase (LOX). LOX is a copper-dependent amine oxidase that oxidatively deaminates specific peptidyl lysine and hydroxylysine residues within its substrates, the best known of which are fibrillar collagens and elastin. The resulting reactive aldehyde residues then spontaneously condense to form covalent intra- and intermolecular cross-linkages leading to the development of insoluble ECM matrices. Besides the cross-linking activity of LOX in the ECM of skin, lung,...

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References

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Authors and Affiliations

  1. John A. Burns School of Medicine, University of Hawaii, 1960 East West Road, Biomedical Sciences Building T415, 96822, Honolulu, HI, USA

    Rozalia Laczko & Katalin Csiszar

Authors
  1. Rozalia Laczko
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  2. Katalin Csiszar
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Corresponding author

Correspondence to Katalin Csiszar .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Laczko, R., Csiszar, K. (2016). Lysyl Oxidase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_244-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_244-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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