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E-NTPDase Family

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Encyclopedia of Signaling Molecules

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Synonyms

ATP diphosphohydrolase; ATPDase; CD39; Ecto-ADPase; Ecto-apyrase; Ecto-ATPase; E-NTPDase; GDA1; NTPDase; Nucleoside triphosphate diphosphohydrolase

Historical Background

Nucleoside triphosphate diphosphohydrolases (NTPDases), originally ATP diphosphohydrolases (ATPDases) with the common name apyrase, are by definition enzymes which split the γ- and β-phosphate residues of triphospho- and diphosphonucleosides such as ATP and ADP, respectively. Before the cloning of the gene, the common name “apyrase” was generally used for enzymes that exhibit this activity in plants and invertebrates while the terms ecto-ATPase and ATP diphosphohydrolase (ATPDase) were rather used in vertebrates (Beaudoin et al. 1996). Shortly after cloning the first gene encoding such an enzyme, the nomenclature was unified in mammals to NTPDase, which better reflects the ability of these enzymes to convert not only ATP and ADP but also other triphospho- and diphosphonucleosides (Zimmermann et al. 1999).

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References

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Authors and Affiliations

  1. Department of Microbiology-Infectiology and Immunology, Faculty of Medicine, Centre de Recherche du CHU de Québec - Université Laval, 2705 Boulevard Laurier, Room T1-49, Quebec City, QC, G1V 4G2, Canada

    Jean Sévigny

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  1. Jean Sévigny
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Correspondence to Jean Sévigny .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Sévigny, J. (2016). E-NTPDase Family. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_197-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_197-1

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