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AIFM1

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 135 Accesses

Synonyms

AIFM1 (Apoptosis-inducing factor, mitochondrion-associated, 1); CMTX-4 (Charcot-Marie-Tooth disease-4); COXPD6 (Combined oxidative phosphorylation deficiency 6); PDCD8 (Programmed cell death protein 8)

Historical Background

Apoptosis-inducing factor (AIF), which is confined to mitochondria of normal healthy cells, was initially described by Kroemer and coworkers (Susin et al. 1999) as the first caspase-independent death effector. Under conditions of cell death induction, AIF is released from mitochondria and translocates to the nucleus where it contributes to chromatin condensation and DNA fragmentation, two features that are classically associated with apoptosis (Hangen et al. 2010a). Since its initial discovery, the structure of the AIF protein has been resolved and the AIFgene has been subjected to genetic manipulations in mice, flies, nematodes, and yeast, revealing the phylogenetically conserved contribution of AIF to cell death, as well as its crucial role in...

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References

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Author information

Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale (INSERM) U1030, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805, Villejuif Cedex, France

    Nazanine Modjtahedi

  2. Gustave Roussy Cancer Campus, Villejuif, France

    Nazanine Modjtahedi

  3. Faculty of Medicine, Université Paris-Saclay, Kremlin-Bicêtre, France

    Nazanine Modjtahedi

  4. Equipe Labellisée Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France

    Guido Kroemer

  5. Institut National de la Santé et de la Recherche Médicale (INSERM) U1138, Paris, France

    Guido Kroemer

  6. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France

    Guido Kroemer

  7. Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Guido Kroemer

  8. Université Pierre et Marie Curie, Paris, France

    Guido Kroemer

  9. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France

    Guido Kroemer

  10. Department of Women’s and Children’s Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Guido Kroemer

Authors
  1. Nazanine Modjtahedi
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  2. Guido Kroemer
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Corresponding author

Correspondence to Nazanine Modjtahedi .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Modjtahedi, N., Kroemer, G. (2016). AIFM1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_174-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_174-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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