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NFAT

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References

  • Aramburu J, Drews-Elger K, Estrada-Gelonch A, Minguillon J, Morancho B, Santiago V, et al. Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5. Biochem Pharmacol. 2006;72:1597–604. doi:10.1016/j.bcp.2006.07.002.

    Article  CAS  PubMed  Google Scholar 

  • Baine I, Abe BT, Macian F. Regulation of T-cell tolerance by calcium/NFAT signaling. Immunol Rev. 2009;231:225–40. doi:10.1111/j.1600-065X.2009.00817.x.

    Article  CAS  PubMed  Google Scholar 

  • Chen L, Glover JN, Hogan PG, Rao A, Harrison SC. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature. 1998;392:42–8. doi:10.1038/32100.

    Article  CAS  PubMed  Google Scholar 

  • Fric J, Zelante T, Wong AY, Mertes A, Yu HB, Ricciardi-Castagnoli P. NFAT control of innate immunity. Blood. 2012;120:1380–9. doi:10.1182/blood-2012-02-404475.

    Article  CAS  PubMed  Google Scholar 

  • Gallo EM, Winslow MM, Cante-Barrett K, Radermacher AN, Ho L, McGinnis L, et al. Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature. 2007;450:731–5. doi:10.1038/nature06305.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hogan PG, Chen L, Nardone J, Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 2003;17:2205–32. doi:10.1101/gad.1102703.

    Article  CAS  PubMed  Google Scholar 

  • Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, et al. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature. 1993;365:352–5. doi:10.1038/365352a0.

    Article  CAS  PubMed  Google Scholar 

  • Li X, Zhu L, Yang A, Lin J, Tang F, Jin S, et al. Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos. Cell Stem Cell. 2011;8:46–58. doi:10.1016/j.stem.2010.11.027.

    Article  CAS  PubMed  Google Scholar 

  • Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol. 2011;12:1063–70. doi:10.1038/ni.2113.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lopez-Rodriguez C, Aramburu J, Jin L, Rakeman AS, Michino M, Rao A. Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress. Immunity. 2001;15:47–58.

    Article  CAS  PubMed  Google Scholar 

  • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol. 2005;5:472–84. doi:10.1038/nri1632.

    Article  CAS  PubMed  Google Scholar 

  • Macian F, Lopez-Rodriguez C, Rao A. Partners in transcription: NFAT and AP-1. Oncogene. 2001;20:2476–89. doi:10.1038/sj.onc.1204386.

    Article  CAS  PubMed  Google Scholar 

  • Mancini M, Toker A. NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer. 2009;9:810–20. doi:10.1038/nrc2735.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Martinez GJ, Hu JK, Pereira RM, Crampton JS, Togher S, Bild N, et al. Cutting edge: NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection. J Immunol. 2016;196:2015–9. doi:10.4049/jimmunol.1501841.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muller MR, Rao A. NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol. 2010;10:645–56. doi:10.1038/nri2818.

    Article  PubMed  Google Scholar 

  • Oh-hora M, Rao A. Calcium signaling in lymphocytes. Curr Opin Immunol. 2008;20:250–8. doi:10.1016/j.coi.2008.04.004.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patra AK, Avots A, Zahedi RP, Schuler T, Sickmann A, Bommhardt U, et al. An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. Nat Immunol. 2013;14:127–35. doi:10.1038/ni.2507.

    Article  CAS  PubMed  Google Scholar 

  • Serfling E, Chuvpilo S, Liu J, Hofer T, Palmetshofer A. NFATc1 autoregulation: a crucial step for cell-fate determination. Trends Immunol. 2006;27:461–9. doi:10.1016/j.it.2006.08.005.

    Article  CAS  PubMed  Google Scholar 

  • Sharma S, Findlay GM, Bandukwala HS, Oberdoerffer S, Baust B, Li Z, et al. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci USA. 2011;108:11381–6. doi:10.1073/pnas.1019711108.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sitara DA, Aliprantis O. Transcriptional regulation of bone and joint remodeling by NFAT. Immunol Rev. 2010;233:286–300. doi:10.1111/j.0105-2896.2009.00849.x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 2006;126:375–87. doi:10.1016/j.cell.2006.05.042.

    Article  CAS  PubMed  Google Scholar 

  • Wu H, Peisley A, Graef IA, Crabtree GR. NFAT signaling and the invention of vertebrates. Trends Cell Biol. 2007;17:251–60. doi:10.1016/j.tcb.2007.04.006.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Fernando Macian .

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Ames, R.Y., Valdor, R., Abe, B.T., Macian, F. (2016). NFAT. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_141-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_141-1

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