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SLC34

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 43 Accesses

Synonyms

Inorganic phosphate transporter type II (a, b or c); NaPi-IIa; NaPi-IIb; NaPi-IIc; NPT2a; NPT2b; NPT2c; Sodium/phosphate cotransporter type 2; Solute carrier family 34 (sodium phosphate)

Historical Background

Phosphorus is one of the six essential elements for life. Molecules containing anionic phosphate (PO4 3−) are constituents of genetic material (DNA, RNA) and are an essential building block of phospholipid membranes, bones, and teeth; high-energy phosphate bonds drive cell energetics via ATP/ADP hydrolysis; phosphorylation/dephosphorylation reactions are key events in intracellular signaling, and phosphate acts as an intra- and extracellular pH buffer. In mammals, phosphate is obtained from the diet in the form of inorganic phosphate (Pi) that exists in solution as negatively charged mono- (H2PO4 −) and divalent (HPO4 2−) ions in the physiological pH range. As such Pimust be actively transported “uphill” across the cell membrane from the external medium against its...

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References

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Author information

Authors and Affiliations

  1. Florey Institute for Neuroscience and Mental Health, Parkville, VIC, 3052, Australia

    Ian Forster

  2. Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK

    Andreas Werner

Authors
  1. Ian Forster
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  2. Andreas Werner
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Correspondence to Ian Forster .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Forster, I., Werner, A. (2017). SLC34. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101997-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101997-1

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  • Print ISBN: 978-1-4614-6438-9

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