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STAT6

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 45 Accesses

Synonyms

IL-4 NAF; IL-4 STAT; Signal transducer and activator of transcription 6; Signal transducer and activator of transcription 6 interleukin-4 induced; STAT interleukin4-induced; STF-IL4; Transcription factor IL-4 STAT

Historical Background

Interleukins (ILs) are a group of cytokines that play an important role in inflammation and immunity (Mizel 1989). They act as ligands by binding to the receptors and generating a response from the cell. The signal received from ILs by their receptors is carried forward by a family of proteins called signal transducers and activators of transcription (STATs), which alter the expression of genes in cells exposed to ILs (Levy and Darnell 2002a). In IL-stimulated cells, the STAT family members are phosphorylated and then translocate to the nucleus, where they act as transcription factors. STAT6, which is a member of the STAT family, was first discovered in 1988 by Boothby et al., (Boothby et al. 1988) as a DNA-binding factor in B cells in which...

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Authors and Affiliations

  1. Institute Life Science 1, School of Medicine, Swansea University, Singleton Park, Swansea, SA2 8PP, Wales, UK

    Benjamin Skalkoyannis & Venkateswarlu Kanamarlapudi

Authors
  1. Benjamin Skalkoyannis
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  2. Venkateswarlu Kanamarlapudi
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Correspondence to Venkateswarlu Kanamarlapudi .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Skalkoyannis, B., Kanamarlapudi, V. (2016). STAT6. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101988-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101988-1

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  • Print ISBN: 978-1-4614-6438-9

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